Abstract:

Objective To investigate the clinical pathological features of breast cancer patients with hypertension and influencing factors of the treatment and chemotherapy. Methods The clinical data and treatments of 186 breast cancer patients with hypertension (the observation group) and 671 breast cancer patients without complications (the control group) were retrospectively analyzed. Results Compared to the control group, the average age of the observation group was older; the rate of postmenopausal patients was higher; and the rate of undergoing chemotherapy was lower. The differences were statistically significant (P<0.001). The differences of tumor size, pathological grade, lymph node status, hormone receptor, and expressions of HER2 and ki67 were not statistically significant (P>0.05). Results of the Logistic regression analysis showed that the age, combined with hypertension, lymph node status, hormone receptor, and expressions of HER2 and ki67 were influencing factors of chemotherapy (P<0.05). Conclusion The differences of clinical pathological features of breast cancer patients with hypertension and breast cancer patients without complications are not significant. The rate of undergoing chemotherapy of breast cancer patients with hypertension is lower than that of breast cancer patients without complications. Combined with hypertension is an important influencing factor for the chemotherapy of breast cancer patients.

Key words: hypertension, breast cancer, chemotherapy