Abstract: Substance dependence is a pervasive worldwide problem, of which the mechanism remains unclear, and there is no effective intervention. In recent years, it has been showed that the gut microbiota is closely related to substance dependence. As discussed in this review, gut microbiota is significantly affectedthe substances of abuse, and may serve as an important regulator in the development of substance dependence. This article reviews the research progress of gut microbiota in the most widely used substances, into provide ideas for future studies on underlying mechanisms and further interventions in substance dependence.

Key words: gut microbiota, substance dependence, alcohol, nicotine, opioids, central nerve system stimulants, cannabis