JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2020, Vol. 40 ›› Issue (10): 1334-1339.doi: 10.3969/j.issn.1674-8115.2020.10.006

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Expression of long noncoding RNA COL11A1-208 in oral squamous cell carcinoma and its clinical significance

JIANG Ying-ying1, 2, QIN Xing1, ZHANG Jian-jun1, CHEN Wan-tao1   

  1. 1. Department of Oral and Maxillofacial-Head & Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China; 2. Department of Preventive Dentistry, School of Stomatology, Weifang Medical University, Weifang 261053, China
  • Online:2020-10-28 Published:2020-11-27
  • Supported by:
    National Natural Science Foundation of China (81874126); Program of Shanghai Science and Technology Commission (18JC1413700); Innovative Research Team of High-Level Local Universities in Shanghai (SSMU-ZLCX20180502).

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Abstract: Objective · To investigate the expression of long noncoding RNA （lncRNA） COL11A1-208 in oral squamous cell carcinoma （OSCC）, and evaluate its potential value in prognosis prediction and diagnosis of OSCC. Methods · The differentially expressed lncRNAs from six pairs of OSCC tissues and the para-carcinoma tissues were detected by lncRNA microarray. Quantitative real-time PCR （qPCR） was used to detect the expression of COL11A1-208 in seventy-four pairs of OSCC tissues and para-carcinoma tissues. The difference of COL11A1-208 expression among the patients with different clinical features were analyzed. The potential effectiveness of COL11A1-208 level in the diagnosis of OSCC was evaluated by the receiver operating characteristic （ROC） curve. Kaplan-Meier survival analysis was used to analyze the effects of COL11A1-208 on the 3-year overall survival rate of OSCC patients. Results · Compared with the para-carcinoma tissues, COL11A1-208 was highly expressed in OSCC tissues （P=0.000）, which was consistent with the results of lncRNA microarray. The expression of COL11A1-208 in the patients with advanced TNM stage （Ⅲ - Ⅳ） was significantly higher than that with TNM stage Ⅰ - Ⅱ （P=0.001）. The area under ROC curve of COL11A1-208 as a biomarker for the diagnosis of OSCC was 0.702 （95%CI 0.617 -0.788, P=0.000）, and the sensitivity and specificity were 87.8% and 54.1%, respectively. The 3-year overall survival rate of the patients with low expression of COL11A1-208 was significantly longer than that of the patients with high expression （P=0.002）. Conclusion · The expression of COL11A1-208 is up-regulated in OSCC tissues, which is even higher in the patients with advanced TNM stage. COL11A1-208 might have potential value in prognostic prediction and diagnosis of OSCC.

Key words: oral squamous cell carcinoma （OSCC）, long noncoding RNA （lncRNA）, COL11A1-208, prognosis, diagnosis

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