JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (1): 16-22.doi: 10.3969/j.issn.1674-8115.2021.01.003

• Basic research • Previous Articles     Next Articles

Association study of synaptotagmin 2 gene polymorphisms with schizophrenia in Chinese Han population

Hong YANG1(), Xin-xin HUANG2, Chao LIU3(), Qing-song LIANG1, Hua YANG1, Jian-biao ZHANG3, Jian XU3, Ying-yi WANG2, Hai-su WU2, Qin-yu LÜ2(), Zheng-hui YI2   

  1. 1.Department of Clinical Psychology, The Fourth People's Hospital of Huaihua, Hunan Province, Huaihua 418000, China
    2.Sixth Clinical Department, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 201108, China
    3.Second Department of Psychiatry, Nantong Fourth People's Hospital, Jiangsu Province, Nantong 226000, China
  • Online:2021-01-28 Published:2021-02-22
  • Contact: Chao LIU,Qin-yu Lü E-mail:yanghong2353357@163.com;ntsylc@163.com;lvqinyu_louis@163.com
  • Supported by:
    Funding Information] National Natural Science Foundation of China(81671326);Shanghai Science and Technology Commission Foundation(17411970000);Project of Jiangsu Provincial Health Committee(H20180400)

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Abstract: Objective

·To investigate the relationship between synaptotagmin 2 (SYT2)gene and schizophrenia (SZ) in Chinese Han population.

Methods

·TaqMan probe genotyping technique was used to detect 5 single nucleotide polymorphism (SNP) sites (rs6427957,rs907697,rs12564274,rs10800856 and rs61820945) of SYT2 gene in 478 SZ patients (SZ group) and 474 healthy controls (HC group). HaploView software, SHEsis and SNPstats online software were used to compare the alleles, genotypes, genotypes under different genetic models and haplotypes frequency distribution between the SZ group and HC group.

Results

·The frequency distribution differences of rs10800856 allele and genotype were statistically significant between the SZ group and HC group, respectively (P=0.003, P=0.012). After Bonferroni correction, the allele frequency difference of rs10800856 site was still statistically significant (P=0.015), while the genotype frequency difference was not statistically significant. Under the dominant and additive genetic mode, the genotype frequency distributions of rs10800856 site were significantly different between the SZ group and HC group (P=0.004, P=0.005). After correction, the differences were still statistically significant (P=0.020, P=0.025). The frequency distribution of haplotype C-T-C, composed of rs12564274-rs10800856-rs61820945, between the SZ group and HC group was significantly different (P=0.009). After Bonferroni correction, the difference was still statistically significant (P=0.036).

Conclusion

·In Chinese Han population, SYT2 may be the susceptibility gene of SZ, and rs10800856 site may be associated with the risk of SZ.

Key words: schizophrenia (SZ), synaptotagmin 2 (SYT2) gene, single nucleotide polymorphism (SNP), association analysis

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