Research progress in epigenetics of obsessive-compulsive disorder

doi:10.3969/j.issn.1674-8115.2021.02.023

Abstract

Abstract:

Obsessive-compulsive disorder is a high disabling psychiatric disease, with unknown etiology. Many studies have shown that the pathogenesis of obsessive-compulsive disorder is associated with both genes and the environment. Epigenetics has provided an approach to explaining the influence on individual inheritance caused by environmental factors. Nowadays, several types of research have proved that there are differences in DNA methylation between obsessive-compulsive disorder patients and healthy population, and the DNA methylation may be strongly related to treatment response. Additionally, an increased level of microRNA was found in patients with obsessive-compulsive disorder. This review summaries the studies of epigenetics of obsessive-compulsive disorder and concludes the possible changes in epigenetic modifications to further understand the pathophysiology of obsessive-compulsive disorder.

Key words: obsessive-compulsive disorder, epigenetics, genetics, DNA methylation, microRNA

CLC Number:

R749.7

Liang-jun LIN, Wei-di WANG, Pei WANG, Guan-ning LIN, Zhen WANG. Research progress in epigenetics of obsessive-compulsive disorder[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(2): 267-272.

Figures/Tables 1

TrendMD

References 60

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Finding	Sample type	Gene	Reference
DNA methylation
Promoter hypomethylation and hyperhydroxymethylation in exonⅠ	Blood	BDNF	[22]
Promoter Ⅳ hypermethylation	Blood	BDNF	[23]
Promoter hypomethylation	Blood	BDNF	[24]
Promoter hypermethylation in children and adolescents, promoter hypomethylation in adults	Saliva	SLC6A4	[25]
Prediction of impaired treatment response of CBT by lower baseline promoter methylation	Blood	SLC6A4	[26]
Promoter hypermethylation	Blood	GABBR1/MOG	[24]
Promoter hypomethylation	Blood	MOG	[24]
Promoter hypomethylation	Blood	ESR1	[24]
Promoter hypermethylation in exon Ⅲ	Blood	OXTR	[27]
Promoter hypermethylation in exon Ⅲ, prediction of impaired treatment response of CBT by higher baseline promoter methylation	Blood	OXTR	[28]
Promoter hypermethylation	Blood	OXTR	[29]
Promoter hypomethylation	Blood	OXTR	[30]
Promoter hypomethylation, higher promoter methylation level after CBT	Blood	MAOA	[31]
Alteration of DNA methylation	Blood	BCYRN1, BCOR, FGF13, etc.	[32]
microRNA
Target gene of miR-485-3p associated with obsessive-compulsive disorder	Blood	NTRK3	[33]
Increased level of miR-22-3p	Blood	BDNF, MAOA, etc.	[34]
Increased level of miR-24-3p	Blood	－	[34]
Increased level of miR-106b-5p	Blood	－	[34]
Increased level of miR-125b-5p	Blood	－	[34]
Increased level of miR-155a-5p	Blood	－	[34]
Increased level of miR-132	Blood	BDNF	[35]
Increased level of miR-134	Blood	BDNF	[35]

Finding	Sample type	Gene	Reference
DNA methylation
Promoter hypomethylation and hyperhydroxymethylation in exonⅠ	Blood	BDNF	[22]
Promoter Ⅳ hypermethylation	Blood	BDNF	[23]
Promoter hypomethylation	Blood	BDNF	[24]
Promoter hypermethylation in children and adolescents, promoter hypomethylation in adults	Saliva	SLC6A4	[25]
Prediction of impaired treatment response of CBT by lower baseline promoter methylation	Blood	SLC6A4	[26]
Promoter hypermethylation	Blood	GABBR1/MOG	[24]
Promoter hypomethylation	Blood	MOG	[24]
Promoter hypomethylation	Blood	ESR1	[24]
Promoter hypermethylation in exon Ⅲ	Blood	OXTR	[27]
Promoter hypermethylation in exon Ⅲ, prediction of impaired treatment response of CBT by higher baseline promoter methylation	Blood	OXTR	[28]
Promoter hypermethylation	Blood	OXTR	[29]
Promoter hypomethylation	Blood	OXTR	[30]
Promoter hypomethylation, higher promoter methylation level after CBT	Blood	MAOA	[31]
Alteration of DNA methylation	Blood	BCYRN1, BCOR, FGF13, etc.	[32]
microRNA
Target gene of miR-485-3p associated with obsessive-compulsive disorder	Blood	NTRK3	[33]
Increased level of miR-22-3p	Blood	BDNF, MAOA, etc.	[34]
Increased level of miR-24-3p	Blood	－	[34]
Increased level of miR-106b-5p	Blood	－	[34]
Increased level of miR-125b-5p	Blood	－	[34]
Increased level of miR-155a-5p	Blood	－	[34]
Increased level of miR-132	Blood	BDNF	[35]
Increased level of miR-134	Blood	BDNF	[35]

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