JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (11): 1425-1428.doi: 10.3969/j.issn.1674-8115.2021.11.004

• Disorders of sex development in children • Previous Articles     Next Articles

Report of 3 cases of 47,XXX syndrome with growth retardation

YANG-Li(), Ya-qin FENG, Yu YANG(), Li-ling XIE, Di-lan WANG, Hui HUANG   

  1. Department of Endocrinology, Genetics and Metabolism, Children's Hospital of Nanchang University/Jiangxi Provincial Children's Hospital, Nanchang 330006, China
  • Online:2021-11-28 Published:2021-10-22
  • Contact: Yu YANG;


To analyze the clinical data of 3 children with growth retardation, including height, chromosome karyotype, and the levels of growth hormone, insulin-like growth factor-1 and gonadal development. All the 3 cases of children were found to be slow in growth rate, no special face, and normal level of insulin-like growth factor-1; the 3 cases all underwent growth hormone provocation test, of which 1 case was partial growth hormone deficiency and 2 cases were idiopathic short; 3 cases of chromosomal karyotypes were 47, XXX, in line with the diagnosis of super-female syndrome.

Key words: 47, XXX syndrome, growth retardation, chromosomal disease, child

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