JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2022, Vol. 42 ›› Issue (2): 235-240.doi: 10.3969/j.issn.1674-8115.2022.02.016

• Review • Previous Articles    

Research progress in the relationship between abnormal blood glucose fluctuation and cognitive dysfunction of patients with diabetes mellitus

Rong ZHANG1(), Li LU1(), Yaxin WANG2, Wenqian DONG1, Yu ZHANG1, Jian ZHOU2()   

  1. 1.Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    2.Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai 200233, China
  • Received:2021-08-31 Online:2022-01-24 Published:2022-01-24
  • Contact: Jian ZHOU;
  • Supported by:
    Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20161430);Shanghai "Rising Stars of Medical Talent" Youth Development Program-Outstanding Youth Medical Talents


Diabetes can not only cause pathological changes in both large vessels and microvessels, but also accelerate the occurrence and development of cognitive dysfunction, increasing the risk of dementia. Studies have shown that diabetes-induced cognitive dysfunction is associated with elevated blood glucose and abnormal glucose fluctuation, and its pathogenesis is closely related to insulin resistance, oxidative stress, cerebrovascular lesions, inflammatory damage, brain cell apoptosis, as well as amyloid β-protein accumulation. At present, drug therapy for diabetic patients with cognitive dysfunction is still in the exploratory stage. It has been found that some hypoglycemic drugs, such as glucagon like peptide -1 receptor agonist, can improve cognitive dysfunction in these patients. However, it still needs to be further clarified by randomized controlled trails with large sample size. This article reviews the assessment methods of cognitive dysfunction, the effects of abnormal glucose fluctuation on cognitive dysfunction, and the pathophysiological mechanisms involved, as well as the effects of different hypoglycemic agents on cognitive dysfunction in patients with diabetes.

Key words: diabetes mellitus, cognitive dysfunction, abnormal blood glucose fluctuation, hypoglycemic agent

CLC Number: