Journal of Shanghai Jiao Tong University (Medical Science) ›› 2023, Vol. 43 ›› Issue (11): 1408-1416.doi: 10.3969/j.issn.1674-8115.2023.11.008
• Clinical research • Previous Articles
LIU Yanyan1(), YANG Tiantian1, SHEN Nanping2(), HE Mengxue3, ZHANG Hongyan4
Received:
2023-06-29
Accepted:
2023-09-12
Online:
2023-10-24
Published:
2023-10-24
Contact:
SHEN Nanping
E-mail:liuyy0621@126.com;shennanping@scmc.com.cn
Supported by:
CLC Number:
LIU Yanyan, YANG Tiantian, SHEN Nanping, HE Mengxue, ZHANG Hongyan. Latent profile analysis of multiple symptom distress in children and adolescents with cancer and its effect on their physical activity[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(11): 1408-1416.
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URL: https://xuebao.shsmu.edu.cn/EN/10.3969/j.issn.1674-8115.2023.11.008
Characteristic | n (%) |
---|---|
Gender | |
Male | 108 (65.5) |
Female | 57 (34.5) |
Age | |
10‒14 years old | 136 (82.4) |
15‒18 years old | 29 (17.6) |
Caregiver | |
Father | 47 (28.5) |
Mother | 118 (71.5) |
Education level of caregiver | |
Primary middle school and lower | 56 (33.9) |
High school/college degree | 61 (37.0) |
Bachelor degree and above | 48 (29.1) |
Family monthly income | |
<2 000 yuan | 13 (7.9) |
2 001‒5 000 yuan | 36 (21.8) |
5 001‒8 000 yuan | 44 (26.7) |
8 001‒10 000 yuan | 34 (20.6) |
>10 000 yuan | 38 (23.0) |
Type of disease | |
Acute lymphoblastic leukemia | 50 (30.3) |
Other leukemia | 13 (7.9) |
Brain tumor | 43 (26.1) |
Lymphoma | 16 (9.7) |
Others | 43 (26.1) |
Risk group | |
Low | 40 (24.2) |
Middle | 78 (47.3) |
High | 47 (28.5) |
Latest visit in hospital | |
Outpatient | 70 (42.4) |
Inpatient | 95 (57.6) |
Treatment | |
Chemotherapy/Radiotherapy/Operation | 68 (41.2) |
Chemotherapy+Radiotherapy | 53 (32.1) |
(Chemotherapy/Radiotherapy)+Operation | 17 (10.3) |
Chemotherapy+Radiotherapy+Operation | 27 (16.4) |
Other health problem | |
No | 154 (93.3) |
Yes | 11 (6.7) |
Anemia | |
No | 112 (67.9) |
Yes | 53 (32.1) |
Tab 1 Clinical and demographic characteristics of children and adolescents with cancer
Characteristic | n (%) |
---|---|
Gender | |
Male | 108 (65.5) |
Female | 57 (34.5) |
Age | |
10‒14 years old | 136 (82.4) |
15‒18 years old | 29 (17.6) |
Caregiver | |
Father | 47 (28.5) |
Mother | 118 (71.5) |
Education level of caregiver | |
Primary middle school and lower | 56 (33.9) |
High school/college degree | 61 (37.0) |
Bachelor degree and above | 48 (29.1) |
Family monthly income | |
<2 000 yuan | 13 (7.9) |
2 001‒5 000 yuan | 36 (21.8) |
5 001‒8 000 yuan | 44 (26.7) |
8 001‒10 000 yuan | 34 (20.6) |
>10 000 yuan | 38 (23.0) |
Type of disease | |
Acute lymphoblastic leukemia | 50 (30.3) |
Other leukemia | 13 (7.9) |
Brain tumor | 43 (26.1) |
Lymphoma | 16 (9.7) |
Others | 43 (26.1) |
Risk group | |
Low | 40 (24.2) |
Middle | 78 (47.3) |
High | 47 (28.5) |
Latest visit in hospital | |
Outpatient | 70 (42.4) |
Inpatient | 95 (57.6) |
Treatment | |
Chemotherapy/Radiotherapy/Operation | 68 (41.2) |
Chemotherapy+Radiotherapy | 53 (32.1) |
(Chemotherapy/Radiotherapy)+Operation | 17 (10.3) |
Chemotherapy+Radiotherapy+Operation | 27 (16.4) |
Other health problem | |
No | 154 (93.3) |
Yes | 11 (6.7) |
Anemia | |
No | 112 (67.9) |
Yes | 53 (32.1) |
Symptom | Number of occurrence | Incidence /% | Distress score/point |
---|---|---|---|
Lack of energy | 143 | 86.7 | 1 (1, 2) |
Nausea | 127 | 77.0 | 1 (1, 2) |
Lack of appetite | 116 | 70.3 | 2 (2, 3) |
Sweat | 108 | 65.5 | 1 (1, 2) |
Pain | 107 | 64.8 | 1 (1, 2) |
Sleepy | 90 | 54.5 | 1 (1, 2) |
Difficuly in concentrating | 90 | 54.5 | 1 (1, 1) |
Hair loss | 85 | 51.5 | 2 (1, 3) |
Cough | 83 | 50.3 | 1 (1, 2) |
Vomiting | 81 | 49.1 | 1 (1, 2) |
Dry mouth | 80 | 48.5 | 1 (1, 2) |
Weight loss | 80 | 48.5 | 1 (1, 2) |
Tab 2 Symptoms incidence rates and distress scores of children and adolescents with cancer
Symptom | Number of occurrence | Incidence /% | Distress score/point |
---|---|---|---|
Lack of energy | 143 | 86.7 | 1 (1, 2) |
Nausea | 127 | 77.0 | 1 (1, 2) |
Lack of appetite | 116 | 70.3 | 2 (2, 3) |
Sweat | 108 | 65.5 | 1 (1, 2) |
Pain | 107 | 64.8 | 1 (1, 2) |
Sleepy | 90 | 54.5 | 1 (1, 2) |
Difficuly in concentrating | 90 | 54.5 | 1 (1, 1) |
Hair loss | 85 | 51.5 | 2 (1, 3) |
Cough | 83 | 50.3 | 1 (1, 2) |
Vomiting | 81 | 49.1 | 1 (1, 2) |
Dry mouth | 80 | 48.5 | 1 (1, 2) |
Weight loss | 80 | 48.5 | 1 (1, 2) |
Item | Physical activity score/ (min·week-1) | Range/ (min·week-1) |
---|---|---|
LPA | 2 530.00 (1 577.50, 3 721.00) | 330.00‒10 570.00 |
MVPA | 70.00 (10.00, 197.50) | 0‒1 820.00 |
Tab 3 Physical activity score of children and adolescents with cancer
Item | Physical activity score/ (min·week-1) | Range/ (min·week-1) |
---|---|---|
LPA | 2 530.00 (1 577.50, 3 721.00) | 330.00‒10 570.00 |
MVPA | 70.00 (10.00, 197.50) | 0‒1 820.00 |
Model | AIC | BIC | aBIC | P value | Entropy | ||
---|---|---|---|---|---|---|---|
LMRT | aLMRT | BLRT | |||||
1 | 5 187.082 | 5 261.625 | 5 185.641 | - | - | - | - |
2 | 4 992.976 | 5 107.896 | 4 990.754 | 0.008 | 0.008 | 0.000 | 0.828 |
3 | 4 949.732 | 5 105.030 | 4 946.729 | 0.413 | 0.418 | 0.000 | 0.862 |
4 | 4 887.739 | 5 083.413 | 4 883.955 | 0.173 | 0.178 | 0.000 | 0.875 |
5 | 4 874.649 | 5 110.701 | 4 870.085 | 0.519 | 0.522 | 0.040 | 0.889 |
Tab 4 Comparison of different latent profile analysis models of symptoms of children and adolescents with cancer
Model | AIC | BIC | aBIC | P value | Entropy | ||
---|---|---|---|---|---|---|---|
LMRT | aLMRT | BLRT | |||||
1 | 5 187.082 | 5 261.625 | 5 185.641 | - | - | - | - |
2 | 4 992.976 | 5 107.896 | 4 990.754 | 0.008 | 0.008 | 0.000 | 0.828 |
3 | 4 949.732 | 5 105.030 | 4 946.729 | 0.413 | 0.418 | 0.000 | 0.862 |
4 | 4 887.739 | 5 083.413 | 4 883.955 | 0.173 | 0.178 | 0.000 | 0.875 |
5 | 4 874.649 | 5 110.701 | 4 870.085 | 0.519 | 0.522 | 0.040 | 0.889 |
Characteristic variable | β | SE | P value | OR | 95%CI |
---|---|---|---|---|---|
Gender | |||||
Female | Ref | ||||
Male | 0.540 | 0.422 | 0.201 | 1.716 | 0.750‒3.925 |
Age | |||||
15‒18 years old | Ref | ||||
10‒14 years old | -0.380 | 0.489 | 0.437 | 0.684 | 0.262‒1.784 |
Type of disease | |||||
Others | Ref | ||||
Acute lymphoblastic leukemia | -1.350 | 0.586 | 0.021 | 3.859 | 1.223‒12.178 |
Other leukemia | -0.230 | 0.761 | 0.763 | 0.795 | 0.179‒3.529 |
Brain tumor | 0.167 | 0.502 | 0.739 | 1.182 | 0.442‒3.163 |
Lymphoma | 0.093 | 0.817 | 0.909 | 1.098 | 0.222‒5.440 |
Risk group | |||||
High risk | Ref | ||||
Low risk | -0.353 | 0.542 | 0.515 | 0.703 | 0.243‒2.033 |
Middle risk | -0.116 | 0.479 | 0.809 | 0.891 | 0.349‒2.275 |
Anemia | |||||
Yes | Ref | ||||
No | -0.437 | 0.407 | 0.283 | 0.646 | 0.291‒1.435 |
Treatment | |||||
Chemotherapy+Radiotherapy+Operation | Ref | ||||
Chemotherapy/Radiotherapy/Operation | -0.950 | 0.680 | 0.162 | 0.387 | 0.102‒1.466 |
Chemotherapy+Radiotherapy | -0.963 | 0.621 | 0.121 | 0.382 | 0.113‒1.290 |
(Chemotherapy/Radiotherapy)+Operation | 0.664 | 0.955 | 0.487 | 1.942 | 0.299‒12.614 |
Last visit in hospital | |||||
Inpatient | Ref | ||||
Outpatient | -0.937 | 0.462 | 0.043 | 0.392 | 0.158‒0.970 |
Tab 5 Analysis on individual characteristic predictors of sympton distress profiles in children and adolescents with cancer
Characteristic variable | β | SE | P value | OR | 95%CI |
---|---|---|---|---|---|
Gender | |||||
Female | Ref | ||||
Male | 0.540 | 0.422 | 0.201 | 1.716 | 0.750‒3.925 |
Age | |||||
15‒18 years old | Ref | ||||
10‒14 years old | -0.380 | 0.489 | 0.437 | 0.684 | 0.262‒1.784 |
Type of disease | |||||
Others | Ref | ||||
Acute lymphoblastic leukemia | -1.350 | 0.586 | 0.021 | 3.859 | 1.223‒12.178 |
Other leukemia | -0.230 | 0.761 | 0.763 | 0.795 | 0.179‒3.529 |
Brain tumor | 0.167 | 0.502 | 0.739 | 1.182 | 0.442‒3.163 |
Lymphoma | 0.093 | 0.817 | 0.909 | 1.098 | 0.222‒5.440 |
Risk group | |||||
High risk | Ref | ||||
Low risk | -0.353 | 0.542 | 0.515 | 0.703 | 0.243‒2.033 |
Middle risk | -0.116 | 0.479 | 0.809 | 0.891 | 0.349‒2.275 |
Anemia | |||||
Yes | Ref | ||||
No | -0.437 | 0.407 | 0.283 | 0.646 | 0.291‒1.435 |
Treatment | |||||
Chemotherapy+Radiotherapy+Operation | Ref | ||||
Chemotherapy/Radiotherapy/Operation | -0.950 | 0.680 | 0.162 | 0.387 | 0.102‒1.466 |
Chemotherapy+Radiotherapy | -0.963 | 0.621 | 0.121 | 0.382 | 0.113‒1.290 |
(Chemotherapy/Radiotherapy)+Operation | 0.664 | 0.955 | 0.487 | 1.942 | 0.299‒12.614 |
Last visit in hospital | |||||
Inpatient | Ref | ||||
Outpatient | -0.937 | 0.462 | 0.043 | 0.392 | 0.158‒0.970 |
Item | Physical activity score/(min·week-1) | Z value | P value | |
---|---|---|---|---|
Low symptom distress group (n=118) | High symptom distress group (n=47) | |||
LPA | 2 311.00 (1 491.25, 3 235.00) | 2 915.00 (2 205.00, 4 025.00) | -2.628 | 0.009 |
MVPA | 70.00 (20.00, 196.25) | 27.00 (0, 210.00) | -1.391 | 0.164 |
Tab 6 Physical activity differences between different symptom distress profiles of children and adolescents with cancer
Item | Physical activity score/(min·week-1) | Z value | P value | |
---|---|---|---|---|
Low symptom distress group (n=118) | High symptom distress group (n=47) | |||
LPA | 2 311.00 (1 491.25, 3 235.00) | 2 915.00 (2 205.00, 4 025.00) | -2.628 | 0.009 |
MVPA | 70.00 (20.00, 196.25) | 27.00 (0, 210.00) | -1.391 | 0.164 |
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