Abstract:

Objective To investigate the prevalence of parenteral nutrition related central venous catheter infection in elder patients with malignant tumors, and explore the risk factors. Methods The clinical data of 366 patients with malignant tumors who were managed with parenteral nutrition after operation were retrospectively analysed. The data of age, gender, body weight, diagnosis of primary disease, surgical approach, past history, volume of blood and albumin transfusion and time of fever (body temperature ≥38 ℃) were collected. Parenteral nutrition related parameters such as time of parenteral nutrition, total calorie, non-protein calorie, amount of fat, protein and glucose, calorie to nitrogen ratio and carbohydrate to fat ratio were also recorded. Results The mean age of 366 patients was (71.8±6.9) years, mean time of parenteral nutrition was (10.6±6.3) d, and total time of catheterization was 3 336 days. The prevalence of parenteral nutrition related central venous catheter infection was 2.5% (9/366). Logistic regression analysis demonstrated that the relative risks of plasma albumin level before parenteral nutrition and time of high fever to catheter infection were 1.257 and 2.518, respectively (P<0.01 for both). Conclusion Plasma albumin level before parenteral nutrition and time of fever were two risk factors for parenteral nutrition related catheter infection in elder patients with malignant tumors.

Key words: elder, tumor, parenteral nutrition, central venous catheter infection