›› 2010, Vol. 30 ›› Issue (2): 225-.

• Review • Previous Articles     Next Articles

Canonical Wnt pathway and schizophrenia

WANG Xue-mei, reviewer；CUI Dong-hong, XIAO Ze-ping, reviser   

  1. Shanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China
  • Online:2010-02-25 Published:2010-02-25
  • Supported by:

    Joint Key Project of New Frontier Technology in Shanghai Municipal Hospitals, SHDC12006105；Hi-Tech Research and Development Program of China, “863”Program, 2007AA02Z420；Shanghai Science and Technology Committee Foundation, 074119520；Program of Shanghai Subject Chief Scientist, 08XD14036；National Natural Science Foundation of China, 30670755

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Abstract:

Schizophrenia is one of the most severe psychiatric disorders. Although the etiology is unknown, schizophrenia appears to be a polygenic disorder associated with environmental factors. There are evidences that intracellular signaling plays an important role in the pathogenesis of schizophrenia. Canonical Wnt pathway, which is closely related to the development and function maintenance of central nervous system, have drawn wide attention. Evidences for potential disturbances of Wnt signaling pathways in schizophrenia have accumulated, which are in favour of the hypothesis that Wnt signaling alterations may be important in the pathogenesis of schizophrenia. The research advances in the relationship between canonical Wnt signaling pathway and schizophrenia are reviewed in this paper.

Key words: canonical Wnt pathway, schizophrenia, neurodevelopment