Abstract:

Objective To analyse the distribution and antibacterial resistance of pathogens in Surgical Intensive Care Unit (SICU) of Xinhua Hospital, School of Medicine, Shanghai Jiaotong University. Methods The pathogenic specimens of 123 patients hospitalized in SICU were collected, and all the specimens were analysed for pathogen distribution and resistance to antibiotics.ResultsA total of 497 strains of pathogenic bacteria were isolated, and Gram-negative bacteria were the most popular pathogens (58.1%), whereas Gram-positive bacteria and fungi accounted for 19.7% and 22.1%, respectively. The most common fungus was Candida albicans (15.1%). Most pathogens were separated from lower respiratory tract (278 strains). The four most common pathogens in all the specimens were Acinetobacter baumannii (20.5%), Pseudomonas aeruginosa (20.5%), Candida albicans (15.8%) and Escherichia Coli (7.9%). Acinetobacter baumannii showed the lowest resistance to cefoperazone-sulbactam (21.0%).The positive rates of the extended spectrum β-lactamases (ESBLs)-producing strains of Escherichia coli and Klebsiella pneumoniae were 49.3% and 40.9%, and there was high sensitivity to imipenem. Gram-positive bacteria were most sensitive to vancomycin and linezolid. Conclusion Epidemiological investigation of pathogens in SICU is of great importance to the rational use of antibiotics and may help to reduce the emergence of resistant strains.

Key words: surgical intensive care unit, pathogen, surveillance of drug resistance