Abstract:

Objective To investigate the relationship between tyrosine kinase receptor B (TrkB) gene polymorphisms and major depressive disorder. Methods The samples of peripheral venous blood of 237 patients with major depressive disorder and 312 healthy controls were collected, and DNA was extracted. Two single nucleotide polymorphisms of TrkB gene were genotyped by TaqMan SNP genotyping assays, and the relationship between gene polymorphisms and major depressive disorder was explored. Results There was no significant difference in genotypes and alleles distribution of TrkB rs1187272 and rs993315 between patients with major depressive disorder and healthy controls (P>0.05). The joint analysis of rs1187272 and rs993315 revealed no significant difference between patients with major depressive disorder and healthy controls. Conclusion TrkB rs1187272 and rs993315 and their haplotypes are not significantly related to major depressive disorder, indicating that TrkB gene polymorphisms may not play important roles in the etiology of major depressive disorder.

Key words: major depressive disorder, tyrosine kinase receptor, polymorphism