JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (11): 1535-1539.doi: 10.3969/j.issn.1674-8115.2021.11.021

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Review of non-invasive brain stimulation for the treatment of somatic symptoms in major depressive disorder

Lin-jie SHEN(), Yu-xin HUANG, Yong WANG(), Hua JIN   

  1. Department of Outpatient, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2021-11-28 Published:2021-10-22
  • Contact: Yong WANG;
  • Supported by:
    Municipal Hospital Clinical Research Cultivation Project of Shanghai Shenkang Hospital Development Center(SHDC12018X24)


The somatic symptoms of major depressive disorder are related to the course of disease, remission rate and severity of clinical symptoms. At present, the first-line treatment is drug therapy, but the adverse effects of drugs often overlap with somatic symptoms. The studies have shown that non-invasive brain stimulation has application values in the treatment of somatic symptoms in major depressive disorder. This paper reviews the current status of repetitive transcranial magnetic stimulation and transcranial direct current stimulation in the treatment of somatic symptoms of major depressive disorder. It also discusses the efficacy of these two types of non-invasive brain stimulation techniques in the treatment of pain and insomnia in the patients with major depressive disorder, as well as the shortcomings of the existing research, and proposes the developing direction of future research.

Key words: non-invasive brain stimulation, major depressive disorder, somatic symptom, repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS)

CLC Number: