›› 2010, Vol. 30 ›› Issue (10): 1285-.doi: 10.3969/j.issn.1674-8115.2010.10.024

• Review • Previous Articles     Next Articles

Research progress on relationship between NMDA receptors and learning and memory

LI Qiang, reviewer；XUE Qing-sheng, YU Bu-wei, reviser   

  1. Department of Anesthesiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, |China
  • Online:2010-10-25 Published:2010-10-27
  • Supported by:

    National Natural Science Foundation of China, 30400421, 30901410

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Abstract:

Long-term potentiation (LTP) is thought to be a model for neuronal plasticity and the neuro-biochemical base of learning and memory. The studies of LTP molecular mechanism focus mainly on N-methyl-D-aspartate (NDMA) receptors. Various combinations of subunits including NR1, NR2, NR3 assemble to form NMDAR and generate diversity in its functions. The effects of NMDA receptors on learning and memory are reviewed in this paper.

Key words: N-methyl-D-aspartate receptor, long-term potentiation, learning, memory