›› 2012, Vol. 32 ›› Issue (6): 820-.doi: 10.3969/j.issn.1674-8115.2012.06.028

• Review • Previous Articles    

Research progress of penicillin-binding proteins and Gram-negative bacterial resistance

WANG Xin-hui, JIANG Yan-qun   

  1. Department of Clinical Laboratory, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2012-06-28 Published:2012-07-02


It has been identified that the modification of penicillin-binding proteins (PBPs) and the reduction of affinity for β-lactams are important mechanisms by which Gram-positive cocci acquire antibiotic resistance. However, among Gram-negative bacteria,the resistance caused by the modification of PBPs has been considered unusual, which neglects the role of PBPs in β-lactams resistance in Gram-negative bacteria.In this paper, the structure, function and research method of PBPs, and the relationship between PBPs and Gram-negative bacterial resistance are reviewed.

Key words: penicillin-binding proteins, Gram-negative bacteria, resistance