›› 2013, Vol. 33 ›› Issue (1): 99-.doi: 10.3969/j.issn.1674-8115.2013.01.020

• Review • Previous Articles     Next Articles

Research progress of Wnt signaling pathway in regulating osteogenic differentiation of mesenchymal stem cells

CHEN Xiao-jing, GAO Yan-hong   

  1. Department of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2013-01-28 Published:2013-02-06
  • Supported by:

    National Natural Science Foundation of China, 81101360； Shanghai Science and Technology Committee Foundation, 12YZ053

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Abstract:

Wnt signaling pathway has been the focus of medical research as it plays a significant role in regulating the growth, development and differentiation of cells. Recent studies have revealed that Wnt signaling pathway may play an important role in regulating the osteogenic differentiation of mesenchymal stem cells (MSCs), the mechanism of which has been the hotspot of bone tissue engineering and provides a new way for the treatment of diseases such as osteoporosis. The research progress of Wnt signaling pathway in regulating osteogenic differentiation of MSCs is reviewed in this paper.

Key words: mesenchymal stem cells, Wnt signaling pathway, osteogenic differentiation, bone formation