›› 2013, Vol. 33 ›› Issue (6): 796-.doi: 10.3969/j.issn.1674-8115.2013.06.020

• Original article (Clinical research) • Previous Articles     Next Articles

Gene polymorphism and linkage disequilibrium of IL-13 and IL-4 in Chinese Han population with chronic periodontitis

CHEN Dong1,2, WANG Li-ming2, ZHANG Jie2, SHU Rong1   

  1. 1.Department of Periodontology, the Ninth People's Hospital, College of Stomatology, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China; 2.Department of Periodontology, Shanghai Stomatological Disease Center, Shanghai 200001, China
  • Online:2013-06-28 Published:2013-06-28
  • Supported by:

    Natural Science Foundation of Shanghai, 10ZR1425900; Shanghai Municipal Health Bureau Foundation, 2009202

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Abstract:

Objective To investigate the gene polymorphism of interleukin (IL)-13 and IL-4 in Chinese Han population with chronic periodontitis, and explore its potential relationship with chronic periodontitis. Methods Matrix-assisted laser desorption ionization time of flight mass spectrometer (MALDI-TOF-MS) was employed to detect the single nucleotide polymorphism (SNP) of rs2070874 and rs1800925 in IL-13 and rs2243248 in IL-14 in chronic periodontitis group (n=278) and healthy control group (n=324), the allele frequency and genotype distribution were calculated, and linkage disequilibrium and haplotype analysis was conducted. Results There were significant differences in the allelic frequency of rs1800925 TT genotype and T allele, as well as that of rs2243248 GG genotype and G allele between chronic periodontitis group and healthy control group (P<0.05). There were also significant differences in the distribution of rs2070874 T/rs1800925 T/rs2243248 G, rs2070874 T/rs1800925 C/rs2243248 G and rs2070874 T/rs1800925 T/rs2243248 T between two groups (P<0.05). Conclusion SNP of rs1800925 in IL-13 gene and rs2243248 in IL-4 gene may be correlated with the susceptibility to chronic periodontitis in Chinese Han population.

Key words: chronic periodontitis, single nucleotide polymorphism, haplotype, interleukin-13, interleukin-4