上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (1): 72-.doi: 10.3969/j.issn.1674-8115.2011.01.017

• 论著（临床研究） • 上一篇    下一篇

乳腺浸润性微乳头状癌的病理特征及其与转移的关系

汪 成1,3, 季 福1, 徐 明2, 包家林3   

  1. 1.上海交通大学 医学院附属仁济医院普外科, 上海 200001；2.上海市黄浦区中心医院病理科, 上海 200002；3.上海市黄浦区中心医院乳腺外科, 上海 200002
  • 出版日期:2011-01-28 发布日期:2011-02-01
  • 通讯作者: 季 福, 电子信箱: jifu1323@163.com。
  • 作者简介:汪 成（1975—）, 男, 主治医师, 硕士生；电子信箱: wangcheng@smmail.cn。

Pathologic features of invasive micropapillary carcinoma of breast and their relationship with lymph node metastasis

WANG Cheng1,3, JI Fu1, XU Ming2, BAO Jia-lin3   

  1. 1.Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, |China；2.Department of Pathology, 3.Department of Breast Surgery, Central Hospital of Huangpu District, Shanghai 200002, China
  • Online:2011-01-28 Published:2011-02-01

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摘要：

目的 探讨乳腺浸润性微乳头状癌（IMPC）的病理学特征及其与淋巴结转移的关系。方法 回顾性分析61例IMPC患者的病理学资料，分析肿瘤T分期（肿瘤大小）、IMPC成分比例、间质淋巴细胞浸润等因素与淋巴结转移的关系。结果 IMPC淋巴管浸润率为73.8%（45/61），淋巴结转移率为75.4%（46/61）。不同T分期患者的淋巴结转移率比较差异无统计学意义（P＞0.05）；肿瘤组织中不同IMPC成分比例患者的淋巴结转移率和淋巴结转移个数比较，差异也无统计学意义（均P＞0.05）；但IMPC间质淋巴细胞浸润阴性患者的淋巴结转移率明显低于间质淋巴细胞浸润阳性者（54.2% vs 62.2%）（P＜0.05）。淋巴结转移灶为纯IMPC成分或以IMPC成分为主（39/43，90.7%）。结论 淋巴管侵袭和区域淋巴结转移是IMPC的生物学特征；IMPC的生物学行为并不取决于肿瘤的大小及肿瘤中IMPC成分的多少，而可能与IMPC成分本身的性质有关。

关键词: 乳腺肿瘤, 浸润性微乳头状癌, 淋巴结转移

Abstract:

Objective To investigate the clinicopathologic features of invasive micropapillary carcinoma (IMPC) of breast, and explore their relationship with lymph node metastasis. Methods The clinical and pathologic features of 61 cases of IMPC of breast were retrospectively analysed, and the relationship between lymph node metastasis and factors such as T staging (tumor size), proportion of components and interstitial lymphocytic infiltration was explored. Results The rate of lymph vascular invasion of IMPC was 73.8%(45/61), and the rate of lymph node metastasis was 75.4%(46/61). There was no significant difference in rates of lymph node metastasis among patients with different T stages (P＞0.05). Besides, there was no significant difference in rates of lymph node metastasis and numbers of lymph node metastasis among different IMPC components in tumor tissues (P＞0.05 for both). However, the rate of lymph node metastasis of patients with IMPC and negative interstitial lymphocytic infiltration (54.2%) was significantly lower than that of patients with IMPC and positive interstitial lymphocytic infiltration (62.2%)(P＜0.05）. The metastatic foci in lymph node were all IMPC components or mainly IMPC components （39/43, 90.7%）. Conclusion Lymph vascular infiltration and regional lymph node metastasis are biological features of IMPC of breast. It is the characteristics of IMPC components instead of the tumor size or amount of IMPC components in the tumor that correlate with the biological behaviors of the tumor.

Key words: breast neoplasm, invasive micropapillary carcinoma, lymph node metastasis