›› 2012, Vol. 32 ›› Issue (1): 111-.doi: 10.3969/j.issn.1674-8115.2012.01.023

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施小凤, 朱 彦   

  1. 江苏大学附属医院血液科, 镇江 212000
  • 出版日期:2012-01-28 发布日期:2012-01-29
  • 通讯作者: 朱 彦, 电子信箱: hgwp62@163.com。
  • 作者简介:施小凤(1977—), 女, 博士生, 主治医生;电子信箱: shixiaofeng1977@163.com。
  • 基金资助:


Homing of mesenchymal stem cells after infusion in vivo

SHI Xiao-feng, ZHU Yan   

  1. Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang 212000, China
  • Online:2012-01-28 Published:2012-01-29
  • Supported by:

    Clinical Medicine Science and Technology Development Foundation of Jiangsu University, JLY20050028



关键词: 间充质干细胞, 归巢, 移植


Mesenchymal stem cells (MSCs) can be isolated from several tissues,  and can also differentiate into disparate tissues. MSCs bear some capabilities such as immunosuppression, tissue repair, accelerating hematopoietic recovery and reducing graft versus host disease(GVHD), which make MSCs the focus of researches. However, the trafficking, homing and survival of MSCs after infusion into animals and their influential factors are not clear. After reviewing  papers, here we reveal some factors influencing homing of MSCs in vivo such as filtration of lung, quantity and culture condition of MSCs and pathologic status of tissues, among which pathologic status (severity of tissue injury) plays a critical role. MSCs preferentially home to sites of tissue injury, the trafficking direction is in line with the chemokine density gradient, and this progress is associated with many ligands and their receptors. Comprehension of homing of mesenchymal stem cells after infusion in vivo may contribute to providing theoretical foundation for clinical utilization of MSCs.

Key words: mesenchymal stem cells, homing, transplantation