›› 2013, Vol. 33 ›› Issue (3): 354-.doi: 10.3969/j.issn.1674-8115.2013.03.020

• 综述 • 上一篇    下一篇

胰岛素基因突变与糖尿病关系的研究进展

李 灿1,2, 刘丽梅1   

  1. 1.上海交通大学附属第六人民医院内分泌代谢科 上海市糖尿病研究所, 上海 200233; 2.苏州大学, 苏州 215006
  • 出版日期:2013-03-28 发布日期:2013-03-29
  • 通讯作者: 刘丽梅, 电子信箱: lmliu@sjtu.edu.cn。
  • 作者简介:李 灿(1985—), 女, 硕士生; 电子信箱: 576085521@163.com。
  • 基金资助:

    国家自然科学基金(81270876, 30771022, 30971384);上海市科委优秀学科带头人基金(10XD1403400)

Research progress of relationship between mutations of insulin gene and diabetes mellitus

LI Can1,2, LIU Li-mei1   

  1. 1.Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, the Sixth People´s Hospital, Shanghai Jiaotong University, Shanghai 200233, China; 2.Suzhou University, Suzhou 215006, China
  • Online:2013-03-28 Published:2013-03-29
  • Supported by:

    National Natural Science Foundation of China, 81270876, 30771022, 30971384; Shanghai Science and Technology Committee Foundation, 10XD1403400

摘要:

胰岛素是由胰岛β细胞分泌的体内惟一的降糖激素。胰岛素基因突变可以导致异常胰岛素病、永久性新生儿糖尿病(PNDM)、青少年成人起病型糖尿病(MODY)以及部分自身抗体阴性的1型糖尿病。文章就胰岛素基因突变与糖尿病关系的研究进展进行综述。

关键词: 胰岛素基因, 突变, 糖尿病

Abstract:

Insulin is the unique hypoglycemic hormone which is secreted by islet β-cells. Insulin gene mutations could result in insulinopathies, permanent neonatal diabetes mellitus (PNDM), maturity onset diabetes of the young (MODY) and auto-antibodies-negative type 1 diabetes mellitus. The research progress of relationship between mutations of insulin gene and diabetes mellitus is reviewed in this article.

Key words: insulin gene, mutation, diabetes mellitus