上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (9): 1309-.doi: 10.3969/j.issn.1674-8115.2017.09.021

• 综述 • 上一篇    

益生菌改善 2 型糖尿病的相关机制

李雪琳，顾燕云，张翼飞   

  1. 上海交通大学 医学院附属瑞金医院内分泌代谢病科，上海 200025
  • 出版日期:2017-09-28 发布日期:2017-10-10
  • 通讯作者: 张翼飞，电子信箱：feifei-a@163.com
  • 作者简介:?李雪琳（1991—），女，硕士生；电子信箱：18701839287@163.com
  • 基金资助:
     上海市教育委员会高峰高原学科建设计划（20161411）

Mechanisms of probiotics to improve type 2 diabetes mellitus#br#

LI Xue-lin, GU Yan-yun, ZHANG Yi-fei   

  1. Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2017-09-28 Published:2017-10-10
  • Supported by:
     Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20161411

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摘要： 肠道内存在着数以万计的微生物群，这些微生物的平衡对维持宿主稳定的肠道内环境和正常的机体代谢至关重要。一旦肠道 菌群结构失调，各种代谢类疾病便随之而来。近年来，肠道菌群与代谢性疾病特别是 2 型糖尿病的相关性研究，已成为国际科学研究 的热点。益生菌作为一类调节宿主肠道微生态平衡的活性微生物，可通过改变肠道菌群及其代谢产物进而改善机体能量代谢、减轻低 水平慢性炎症和氧化应激反应。益生菌的应用已逐渐成为预防和控制 2 型糖尿病的常用方法。该文概述了益生菌的摄入对宿主肠道菌 群的影响和改善 2 型糖尿病的相关机制的研究进展，以期为益生菌的临床应用提供理论参考。

关键词:  2 型糖尿病, 益生菌, 肠道菌群, 短链脂肪酸, 胆汁酸

Abstract:

There are tens of thousands of microbiota in the intestine, and the balance of these microbiota is essential to maintain intestinal stability and body metabolism. Once the intestinal flora structure is disordered, a variety of metabolic diseases will follow. In recent years, the international scientific researches focus on the relationship between intestinal flora and metabolic diseases, especially type 2 diabetes mellitus (T2DM). And the probiotics, as a kind of active microorganism that regulate the micro-ecological balance of the host's gut, can change the intestinal flora and their metabolites, and thus improve the host energy metabolism and reduce low level chronic inflammation and oxidative stress. Therefore, its intake has gradually become an usual method of preventing and controlling T2DM. This review provides an overview of the effects of probiotics on host intestinal flora and the mechanisms of improving T2DM, as well as a theoretical reference for the clinical application of probiotics.

Key words:  type 2 diabetes mellitus, probiotics, intestinal flora, short chain fatty acids, bile acids