上海交通大学学报(医学版) ›› 2022, Vol. 42 ›› Issue (8): 1116-1121.doi: 10.3969/j.issn.1674-8115.2022.08.017
• 综述 • 上一篇
收稿日期:
2022-07-03
接受日期:
2022-08-10
出版日期:
2022-08-28
发布日期:
2022-10-08
通讯作者:
刘珅
E-mail:2020323672@sjtu.edu.cn;liushensjtu@126.com
作者简介:
沙 攀(2002—),女,本科生;电子信箱:2020323672@sjtu.edu.cn。
基金资助:
SHA Pan(), ZHAO Xuewen, ZHU Haotian, GAO Chongzhou, LIU Shen()
Received:
2022-07-03
Accepted:
2022-08-10
Online:
2022-08-28
Published:
2022-10-08
Contact:
LIU Shen
E-mail:2020323672@sjtu.edu.cn;liushensjtu@126.com
Supported by:
摘要:
肌腱粘连是肌腱损伤修复术后常见的并发症,其治疗棘手,是当前临床上亟待攻克的难题之一。近年来,随着医学科学的不断更新与发展,肌腱愈合机制研究不断深入,为术后肌腱粘连的防治与功能恢复提供了理论依据。防治肌腱粘连的关键在于抑制外源性愈合和炎症反应以及促进内源性愈合。肌腱粘连的发生主要与转化生长因子-β(transforming growth factor-β,TGF-β)、碱性成纤维细胞生长因子、血管内皮生长因子等细胞因子有关,另外TGF-β/Smad信号转导通路也较为重要。临床上改进缝合方法及早期康复活动对肌腱粘连的防治具有关键作用,其原理与力学载荷对细胞行为的影响相关;材料联合药物是当前防治肌腱粘连的研究热点,现有的防粘连膜主要发挥物理屏障作用,负载药物后通过抑制炎症反应、调控细胞增殖代谢、抗氧化应激、抑制TGF-β等途径可以实现高效抑制粘连。该文就近年来肌腱粘连的机制以及防治手段中手术、康复、材料、药物等方面的研究进展作一综述,以期促进基础研究的转化应用,为临床防治肌腱粘连提供参考。
中图分类号:
沙攀, 赵雪雯, 朱浩天, 高崇洲, 刘珅. 肌腱粘连的机制及干预研究进展[J]. 上海交通大学学报(医学版), 2022, 42(8): 1116-1121.
SHA Pan, ZHAO Xuewen, ZHU Haotian, GAO Chongzhou, LIU Shen. Research progress in the mechanism and intervention of tendon adhesion[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(8): 1116-1121.
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