上海交通大学学报（医学版）

›› 2009, Vol. 29 ›› Issue (11): 1351-.

• 论著（临床研究） • 上一篇    下一篇

首发精神分裂症患者N400神经发生源的研究

陈兴时1, 唐云翔2, 肖泽萍3, 王继军4, 张明岛1, 张载福5, 胡珍玉6, 陈中鸣6, 楼翡璎1, 陈 冲1, 杨 杰1   

  1. 1. 上海交通大学 医学院上海市精神卫生中心 神经生理室, 上海 200030；2. 第二军医大学 心理学教研室, 上海 200433；上海交通大学 医学院上海市精神卫生中心 3. 精神科；4. 脑电影像室, 上海 200030；5. 浙江省金华市第二医院 精神科, 金华 321016；6. 浙江省宁波市康宁医院 精神科, 宁波 315201
  • 出版日期:2009-11-25 发布日期:2009-11-24
  • 通讯作者: 唐云翔, 电子信箱: tangyunxiang1973@tom.com；王继军, 电子信箱: oukeigun@yahoo.com.cn。
  • 作者简介:陈兴时（1957—）, 男, 教授；电子信箱: chenxingshi2008@163.com。
  • 基金资助:

    国家自然科学基金（30770772, 30971046）和国家高技术研究发展计划（“863”计划）（2008AA02Z412，2007AA02Z420）；上海市科学技术委员会2007年创新行动计划（7411950）

Study on neural generators of N400 in first episode schizophrenia

CHEN Xing-shi1, TANG Yun-xiang2, XIAO Ze-ping3, WANG Ji-jun4, ZHANG Ming-dao1, ZHANG Zai-fu5, HU Zhen-yu6, CHEN Zhong-ming6, LOU Fei-ying1, CHEN Chong1, YANG Jie1   

  1. 1. Department of Electrophysiology, Shanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China|2. Department of Psychology, The Second Military Medical University, Shanghai 200433, China|3. Department of Psychiatry, 4. Department of Electronic Encephalography Source Imaging, Shanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030|5. Department of Psychiatry, Jinhua The Second Hospital, Jinhua 321016, China|6. Department of Psychiatry, Ningbo Kangning Hospital, Ningbo 315201, China
  • Online:2009-11-25 Published:2009-11-24
  • Supported by:

    National Natural Science Foundation of China, 30770772, 30971046；National High Technology Research and Development Program of China, “863” Program, 2008AA02Z412, 2007AA02Z420；Shanghai Science and Technology Committee Foundation, 7411950

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摘要：

目的 探讨首发精神分裂症患者汉语句子结尾词匹配和非匹配事件相关脑电位(ERP)N400的特点及其神经发生源。方法 应用WJ-1型ERP仪，对56例首发精神分裂症患者使用76个汉语句子（31句匹配，45句非匹配）进行刺激，诱发N400，经脑地形图分析软件对N400差异波105~615 ms时间窗口内的神经发生源进行研究。结果 ①在首发精神分裂症患者中，语义非匹配较语义匹配的N400潜伏期长，波幅高（P<0.05或P<0.01）；②汉语句子诱发的N400广泛分布于脑部各区，N400波型明显。③N400在345~405 ms时，主要激活额区；在420~570 ms时，可激活多个脑区，以中央区激活最显著。结论 首发精神分裂症患者汉语句子N400神经发生源可能是多源性、多部位共同作用的结果，以额区最为活跃。

关键词: 精神分裂症, N400, 神经发生源, 事件相关脑电位, 汉语句子, 脑地形图

Abstract:

Objective To explore the features and neural generators of the events related potentials (ERP) component N400, elicited by congruent and incongruent ending sentences, in first episode schizophrenia patients. Methods N400 was elicited by 76 congruent (31) or incongruent (45) ending Chinese sentences paradigm, and recorded by WJ-1 ERP instruments in 56 first episode schizophrenia. The neural generators of N400 different wave in 105-615 ms time windows were analyzed by Brain Electrical Activity Mapping software. Results ① The N400 latencies were significantly longer and amplitudes significantly higher in incongruent conditions than in congruent conditions in first episode schizophrenia (P<0.05 or P<0.01). ② N400 elicited by Chinese sentences distributed on frontal, parietal, occipital and temporal regions, and had a clear waveform. ③ The main brain areas activated by N400 were frontal areas in 345-405 ms time windows, and central areas in 420-570 ms time windows. Conclusion N400 elicited by Chinese sentences are multi-generated in first episode schizophrenia, especially in frontal area.

Key words: schizophrenia, N400, neural generators, event related potentials, Chinese sentences, brain electrical activity mapping