上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (1): 13-.

• 专题报道（营养学研究） • 上一篇    下一篇

植物甾醇对大鼠脂质代谢紊乱的预防作用

杨科峰, 房玥晖, 张 雄, 杨 敏   

  1. 上海交通大学 医学院营养系, 上海 200025
  • 出版日期:2010-01-26 发布日期:2010-01-26
  • 作者简介:杨科峰（1973—）, 男, 讲师, 博士生；电子信箱: yangkf73@yahoo.com.cn。
  • 基金资助:

    上海市教委科研创新项目（09YZ98）

Preventive effects of phytosterol on lipid metabolic disturbance of rats

YANG Ke-feng, FANG Yue-hui, ZHANG Xiong, YANG Min   

  1. Department of Nutrition, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2010-01-26 Published:2010-01-26
  • Supported by:

    Shanghai Education Committee Foundation, 09YZ98

PDF (PC)

1477

摘要：

目的 研究植物甾醇对高脂饮食大鼠脂质代谢的影响。方法 40只雄性SD大鼠随机分为基础对照组（普通饲料喂养）、高脂模型组（高脂饲料喂养）、植物甾醇低剂量组（高脂饲料喂养，每天100 mg/kg植物甾醇灌胃）和植物甾醇高剂量组（高脂饲料喂养，每天200 mg/kg植物甾醇灌胃）。分别于实验结束时（6周末）测定各组大鼠的体质量、血脂水平、肝脏脂肪含量及体脂含量。结果 实验结束时，3组高脂饮食大鼠的体质量、肝脏脂肪含量、体脂含量以及血清TC、TG、LDL-C水平均明显高于基础对照组（P<0.05），血清HDL-C水平低于基础对照组（P<0.05）。与高脂模型组比较，植物甾醇高剂量组大鼠的体质量增加量较少（P<0.05），体脂含量较低（P<0.05）；植物甾醇低、高剂量组大鼠肝脏脂肪含量及血清TC、TG和LDL-C水平均显著低于高脂模型组（P<0.05）。结论 植物甾醇具有预防高脂饮食大鼠脂质代谢紊乱的作用。高剂量植物甾醇可减少高脂饮食大鼠体质量的增加和体脂含量。

关键词: 植物甾醇, 脂质代谢, 高脂饮食, 肥胖

Abstract:

Objective To investigate the preventive effects of phytosterol on lipid metabolic disturbance of rats fed with high-fat diet. Methods Forty male SD rats were randomly divided into control group (fed with basic diet), high-fat model group (fed with high-fat diet), low phytosterol group（fed with high-fat diet and 100 mg/kg phytosterol) and high phytosterol group（fed with high-fat diet and 200 mg/kg phytosterol). Body weight, serum lipid, liver fat and body fat were measured at the end of experiment (6 weeks later). Results At the end of experiment, the body weight, contents of liver fat and body fat and serum TC, TG and LDL-C levels were significantly higher in high-fat model group, low phytosterol group and high phytosterol group than those in control group (P<0.05), while serum HDL-C levels in these three groups were significantly lower than that in control group (P<0.05). Compared with high-fat model group, the body weight gain and content of body fat of high phytosterol group were significantly lower (P<0.05). The contents of liver fat and serum TC, TG and LDL-C levels in low phytosterol group and high phytosterol group were significantly lower than those of high-fat model group (P<0.05). Conclusion Phytosterol could prevent lipid metabolic disturbance of rats fed with high-fat diet. High dose phytosterol has the potential to reduce the body weight gain and contents of body fat of rats fed with high-fat diet.

Key words: phytosterol, lipid metabolism, high-fat diet, obesity