上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (11): 1424-.doi: 10.3969/j.issn.1674-8115.2010.11.026

• 综述 • 上一篇    下一篇

氯氮平与代谢综合征的研究进展

陈剑华1,2, 刘登堂2, 李 岩2, 徐一峰2   

  1. 1.复旦大学附属华山医院精神医学教研室, 上海 200021； 2.上海交通大学 医学院附属精神卫生中心, 上海 200030
  • 出版日期:2010-11-25 发布日期:2010-11-29
  • 作者简介:陈剑华（1981—）, 男, 住院医师, 硕士生；电子信箱: chenjhv@hotmail.com。

Research progress of relationship between clozapine and metabolic syndrome

CHEN Jian-hua1,2, LIU Deng-tang2, LI Yan2, XU Yi-feng2   

  1. 1.Department of Psychiatry, Huashan Hospital, Fudan University, Shanghai 200021, China；2.Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China
  • Online:2010-11-25 Published:2010-11-29

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摘要：

代谢综合征是一组心血管疾病的危险因素，包括糖尿病、空腹血糖升高、中心性肥胖、高胆固醇和高血压等。非典型抗精神病药中，氯氮平对体质量、血脂浓度和血糖控制具有不良作用，可导致代谢异常的风险加大。文章通过检索国内外近年文献，明确代谢综合征的概念，综述抗精神病药氯氮平与代谢综合征的关系。

关键词: 抗精神病药, 精神分裂症, 代谢综合征

Abstract:

Metabolic syndrome, including diabetes, increased fasting plasma glucose, abdominal obesity, high cholesterol and high blood pressure, is a cluster of risk factors for cardiovascular diseases. Clozapine is one of the atypical antipsychotics which have negative effects on body weight, plasma lipid concentration and plasma glucose control, and may increase the risks of suffering from metabolic syndrome. The relationship between clozapine and metabolic syndrome is reviewed in this paper.

Key words: antipsychotics, schizophrenia, metabolic syndrome