上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (11): 1540-.doi: 10.3969/j.issn.1674-8115.2011.11.008

• 专题报道（双相障碍） • 上一篇    下一篇

双相障碍免疫机制的研究进展

洪 武, 方贻儒   

  1. 上海交通大学 |医学院附属精神卫生中心心境障碍科, 上海 200030
  • 出版日期:2011-11-28 发布日期:2011-11-29
  • 通讯作者: 方贻儒, 电子信箱: yirufang@yahoo.com.cn。
  • 作者简介:洪 武（1977—）, 女, 主治医师, 博士；电子信箱: drhongwu@126.com。
  • 基金资助:

    国家自然科学基金（81000581, 30971047）；国家高技术研究发展计划（“八六三”计划）(2006AA02Z430)；上海交通大学医学院“重点学科建设”基金（沪交医科[2008]-6）；上海交通大学医学院附属精神卫生中心院级课题（2011-YJ-06）

Research progress of immunological mechanisms of bipolar disorder

HONG Wu, FANG Yi-ru   

  1. Department of Mood Disorder, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China
  • Online:2011-11-28 Published:2011-11-29
  • Supported by:

    National Natural Science Foundation of China, 81000581, 30971047；National High Technology Research and Development Program of China, “863” Program, 2006AA02Z430；Shanghai Jiaotong University School of Medicine Foundation, 2008-6；Shanghai Mental Health Center Foundation, 2011-YJ-06

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摘要：

目前，双相障碍的发病机制尚不清楚。除了遗传因素外，还可能与神经递质、神经营养、氧化应激、免疫炎症和环境等因素相关，并且可能是以上各种因素相互作用的结果，其中免疫炎症机制是近年来关注的热点之一。该文总结了双相障碍免疫机制相关基因多态性研究和细胞因子水平研究，并探讨双相障碍与免疫异常之间的因果关系以及免疫相关方法在双相障碍诊断和治疗中的应用前景。

关键词: 双相障碍, 免疫学, 细胞因子

Abstract:

The pathogenesis of bipolar disorder has not been clearified. Heredity, neurotransmitter, neurotrophy, oxidative stress, immunology and environment have been reported to be related to the pathogenesis of bipolar disorder. Nowadays, the relationship between bipolar disorder and immunity has become the focus of attention. This review summarizes the immunity-related gene polymorphisms and cytokines in the pathogenesis of bipolar disorder, discusses the causal relationship between bipolar disorder and dysimmunity, and explore the application of immunity-related methods in the diagnosis and treatment of bipolar disorder.

Key words: bipolar disorder, immunology, cytokine