上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (12): 1746-.doi: 10.3969/j.issn.1674-8115.2011.12.019

• 论著（临床研究） • 上一篇    下一篇

布地奈德雾化吸入对全身麻醉气管插管术后咽喉部并发症的缓解作用

陈燕青1,2, 王家东1,2, 徐雅男1,2, 肖 洁3   

  1. 上海交通大学 1.医学院附属仁济医院耳鼻咽喉头颈外科, 2.耳鼻咽喉科研究所, 3.医学院附属仁济医院麻醉科, 上海 200127
  • 出版日期:2011-12-28 发布日期:2012-01-04
  • 通讯作者: 王家东, 电子信箱: drjiadongw@yahoo.com.cn。
  • 作者简介:陈燕青（1979—）, 女, 住院医师, 硕士；电子信箱: doc_angela@hotmail.com。

Effects of budesonide suspension inhalation on relieving postoperative throat complications after tracheal intubation under general anesthesia

CHEN Yan-qing1,2, WANG Jia-dong1,2, XU Ya-nan1,2, XIAO Jie3   

  1. 1.Department of Otolaryngology-Head &|Neck Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, 2.Otolaryngology Institute of Shanghai Jiaotong University, 3.Department |of Anesthesia, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2011-12-28 Published:2012-01-04

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摘要：

目的 观察布地奈德雾化吸入对改善全身麻醉气管插管患者术后咽喉部不适的疗效。方法 110例全身麻醉下行气管插管的甲状腺良性肿瘤患者随机分为A组（n=40，予以布地奈德2 mg术前1 h、术后6、24和48 h雾化吸入）、B组（n=40，予以布地奈德2 mg术后6、24和48 h雾化吸入）和对照组（n=30，术后同时段予以生理盐水雾化吸入）。观察各组患者术后咽喉部情况，评价不同方式雾化吸入对患者气管插管后咽喉部症状和体征的疗效。结果 所有患者术后咽痛、咳嗽和声嘶症状的发生率分别为99%、13.6%和53.6%。A组术后各时段的咽痛症状及术后1、6和24 h声嘶症状评分优于B组（P<0.05）；B组与对照组术后48 h的咽痛和声嘶症状评分差异有统计学意义（P<0.05），其他各时段差异均无统计学意义（P>0.05）；三组咳嗽症状评分差异无统计学意义（P>0.05）。A组术后1、6和24 h咽喉部黏膜反应评分优于B组和对照组，B组术后6、24和48 h评分优于对照组（P<0.05）。结论 布地奈德雾化吸入能有效减轻全身麻醉气管插管引起的咽喉部损伤，术前给药能起到一定的预防作用。

关键词: 布地奈德, 雾化吸入, 气管插管, 咽喉部并发症

Abstract:

Objective To investigate the effects of budesonide suspension inhalation on relieving postoperative throat complications after tracheal intubation under general anesthesia. Methods One hundred and ten patients with benign thyroid tumors undergoing tracheal intubation under general anesthesia were randomly divided into group A (n=40, 2 mg budesonide suspension inhalation 1 h before operation and 6 h, 24 h and 48 h after operation), group B (n=40, 2 mg budesonide suspension inhalation 6 h, 24 h and 48 h after operation) and group C (n=30, inhalation of normal saline 6 h, 24 h and 48 h after operation). The conditions of throat were observed in each group after operation, and the effectiveness of different methods of suspension inhalation in signs and symptoms after tracheal intubation was evaluated in each group. Results The incidences of sore throat, cough and hoarseness after operation in all patients were 99%, 13.6% and 53.6% respectively. The scoring of sore throat at each time point after operation and hoarseness 1 h, 6 h and 24 h after operation in group A was better than that in group B （P<0.05）. There were significant differences in the scoring of sore throat and hoarseness 48 h after operation between group B and control group （P<0.05）, while there was no significant difference in the scoring of sore throat and hoarseness at the other time points between two groups （P＞0.05）. There was no significant difference in the scoring of cough among three groups （P＞0.05）. The scoring of mucosa reaction of throat 1 h, 6 h and 24 h after operation in group A was better than that in group B and control group, and the scoring of mucosa reaction of throat 6 h, 24 h and 48 h after operation in group B was better than that in control group （P<0.05）. Conclusion Inhalation of budesonide suspension is effective in reducing the throat injury caused by tracheal intubation under general anesthesia, and preoperative administration may have preventive function to some degree.

Key words: budesonide, suspension inhalation, tracheal intubation, throat complications