上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (4): 501-.doi: 10.3969/j.issn.1674-8115.2011.04.028

• 综述 • 上一篇    下一篇

BMP-7介导的间叶-上皮转化与器官纤维化研究进展

陈丽丽, 虢灿杰, 陈源文, 沈 峰, 李定国   

  1. 上海交通大学 医学院附属新华医院消化科, 上海 200092
  • 出版日期:2011-04-28 发布日期:2011-04-28
  • 通讯作者: 李定国, 电子信箱: dingguo_li@xinhuamed.com.cn。
  • 作者简介:陈丽丽（1985—）, 女, 硕士；电子信箱: cllen103@hotmail.com。
  • 基金资助:

    国家自然科学基金（30971332）

Research progress of BMP-7 induced mesenchymal to epithelial transition in organ fibrosis

CHEN Li-li, GUO Can-jie, CHEN Yuan-wen, SHEN Feng, LI Ding-guo   

  1. Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2011-04-28 Published:2011-04-28
  • Supported by:

    National Natural Science Foundation of China, 30971332

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摘要：

纤维化是各种器官慢性损伤的共同结果。研究发现上皮-间叶转化（EMT）可能是导致多种器官纤维化的潜在机制。目前认为转化生长因子-β1（TGF-β1）能诱导EMT，促进器官纤维化，而骨形态发生蛋白-7（BMP-7）可通过拮抗TGF-β的作用，诱导间叶-上皮转化，改善多种器官纤维化。然而，至今BMP-7的抗纤维化分子机制仍不清楚，对其进行深入研究具有重要意义，可能提供一种纤维化疾病的新治疗手段。

关键词: 骨形态发生蛋白-7, 器官纤维化, 间叶-上皮转化, 上皮-间叶转化

Abstract:

Fibrosis is a common result of chronic injury in many organs. Studies have revealed that epithelial to mesenchymal transition might be the underlying mechanism of fibrotic disorder. Transforming growth factor-β1 has been suggested to induce epithelial to mesenchymal transition and promote organ fibrosis. In contrast, bone morphogenetic protein-7 can block the effect of transforming growth factor-β and induce mesenchymal to epithelial transition which may be helpful to improve organ fibrosis. However, the molecular mechanism of anti-fibrotic effect of bone morphogenetic protein-7 remains unclear. Further studies are of great significance and may provide new therapeutic strategies for organ fibrosis.

Key words: bone morphogenic protein-7, organ fibrosis, mesenchymal to epithelial transition, epithelial to mesenchymal transition