上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (4): 497-.doi: 10.3969/j.issn.1674-8115.2011.04.027

• 综述 • 上一篇    下一篇

翼螺旋转录因子Foxa2与糖脂代谢及糖尿病关系的研究进展

陆 明, 刘丽梅   

  1. 上海交通大学附属第六人民医院内分泌代谢科 上海市糖尿病研究所, 上海 200233
  • 出版日期:2011-04-28 发布日期:2011-04-28
  • 通讯作者: 刘丽梅, 电子信箱: lmliu@sjtu.edu.cn。
  • 作者简介:陆 明(1984—), 女, 硕士生；电子信箱: lumingwyp@yahoo.com.cn。
  • 基金资助:

    国家自然科学基金(30771022)和上海市科委基金（10XD1403400）

Research progress of relationship between forkhead transcription factor Foxa2 and glucose and lipid metabolism and diabetes mellitus

LU Ming, LIU Li-mei   

  1. Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, The Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2011-04-28 Published:2011-04-28
  • Supported by:

    National Natural Science Foundation of China, 30771022；Shanghai Science and Technology Committee Foundation, 10XD1403400

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摘要：

翼螺旋转录因子Foxa2是调节胰腺发育及糖、脂代谢的重要转录因子。作为胰岛素信号的下游靶标，大脑中Foxa2的结构性激活，引起食物消耗、代谢及胰岛素敏感性增加。Foxa2参与葡萄糖和脂质代谢通路的基因表达调节，改善外周组织胰岛素抵抗，是新的胰岛素敏感性转录调节因子；该蛋白的磷酸化通过细胞定位改变而引起失活。该文就Foxa2与糖脂代谢及糖尿病关系的研究进展进行综述。

关键词: Foxa2, 糖脂代谢, 糖尿病

Abstract:

Forkhead transcription factor Foxa2 is an important transcription factor regulating pancreatic development and glucose and lipid metabolism. As a downstream target of insulin signaling, constitutive activation of Foxa2 in the brain results in increased food consumption, metabolism and insulin sensitivity. Foxa2 regulates gene expression involved in glucose and lipid metabolism pathway, improves insulin resistance in peripheral tissues, and has been recognized as a novel transcription factor of insulin sensitivity. Phosphorylation of the protein results in Foxa2's inactivation by its localization changing from nuclei to cytosol. The research progress of relationship between Foxa2 and glucose and lipid metabolism and diabetes mellitus is reviewed in this paper.

Key words: Foxa2, glucose and lipid metabolism, diabetes mellitus