上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (4): 505-.doi: 10.3969/j.issn.1674-8115.2011.04.029

• 综述 • 上一篇    下一篇

胃癌相关血清标志物的临床意义及研究进展

葛沁怡1,2, 胡梅洁1   

  1. 上海交通大学 |医学院附属瑞金医院 1.卢湾分院消化内科, 2.临床医学院, 上海 200025
  • 出版日期:2011-04-28 发布日期:2011-04-28
  • 作者简介:葛沁怡（1986—）, 女, 硕士生；电子信箱: tiffanyttg@gmail.com。

Clinical value and research advances of serum tumor markers in gastric cancer

GE Qin-yi1,2, HU Mei-jie1   

  1. 1.Department of Gastroenterology, Ruijin Hospital Luwan Branch, 2.Department of Clinical Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2011-04-28 Published:2011-04-28

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摘要：

胃癌是我国最常见的消化道恶性肿瘤之一，早期诊断、早期治疗是提高患者生存期及降低病死率的关键。血清肿瘤标志物检测具有无创、标准化等特点，是近年来众多学者研究的热点。该文针对基因与蛋白水平中近期研究较多的4种胃癌相关的血清标志物（E-cadherin、Runx3、hGC-1和VEGF家族的三个亚型) 作一综述，并分析其对于诊断早期胃癌、监测病情变化及判断预后的应用价值。

关键词: 胃癌, 肿瘤标志物, 血清, 诊断, 预后, DNA甲基化

Abstract:

Gastric carcinogenesis is one of the most commonly occurring malignant neoplasms in China, and early diagnosis and treatment are crucial to improving the quality of life and reducing mortality rates for patients with gastric cancer. Serumbased detection methods allow for a standardized and non-invasive approach to monitoring progression of gastric cancer. We therefore summarize four serum-based biomarkers (E-cadherin, Runx3, hGC-1 and 3 subtypes of VEGF family) for gastric cancer, categorized into groups of genes and proteins, and evaluate their individual values in detecting gastric cancer, surveillance and evaluating prognosis of patients with gastric cancer.

Key words: gastric cancer, biomarker, serum, diagnosis, prognosis, DNA methylation