上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (7): 1035-.doi: 10.3969/j.issn.1674-8115.2011.07.037

• 综述 • 上一篇    下一篇

类风湿性关节炎免疫学研究进展

缪 怡1,2, 胡朝英2, 钱 柳1, 张冬青1   

  1. 1.上海交通大学医学院 上海市免疫学研究所, 上海 200025； 2.上海市徐汇区中心医院, 上海 200031
  • 出版日期:2011-07-28 发布日期:2011-07-27
  • 通讯作者: 张冬青, 电子信箱: dqzhang1333@yahoo.com.cn。
  • 作者简介:缪 怡（1976—）, 女, 主管技师, 硕士生；电子信箱: miaoyi040123@yahoo.cn。
  • 基金资助:

    上海市徐汇区中心医院院基金(2011XHCH07)和上海市科委重点项目（07JC14033和10JC1408500）

Research progress in immunology of rheumatoid arthritis

MIAO Yi1,2, HU Chao-ying2, QIAN Liu1, ZHANG Dong-qing1   

  1. 1.Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China；2.Xuhui District Center Hospital of Shanghai, Shanghai 200031, China
  • Online:2011-07-28 Published:2011-07-27
  • Supported by:

    Foundation of Xuhui District Center Hospital of Shanghai, 2011XHCH07；Key Project of Shanghai Science and Technology Committee, 07JC14033, 10JC1408500

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摘要：

类风湿性关节炎（RA）是一类常见的、以四肢关节滑膜炎为特征的慢性自身免疫性疾病。RA是以T淋巴细胞，特别是辅助性T淋巴细胞亚群Th1细胞介导为核心的免疫系统功能紊乱性疾病；B淋巴细胞通过递呈抗原、产生自身抗体和分泌细胞因子也与RA发病密切相关。此外，γδ T淋巴细胞、Th17细胞及细胞因子白介素4（IL-4）和IL-10等也在不同程度上影响着疾病的进程。文章就细胞、抗体和细胞因子与RA发病和诊疗的相关性作一综述。

关键词: 类风湿性关节炎, 自身免疫性疾病, T淋巴细胞, B淋巴细胞, 自身抗体

Abstract:

Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic inflammation of synovial joints. RA is presented as the malfunction of immune system especially mediated by Th1 cells. B lymphocytes are also closely associated with RA in the process of antigen presentation, antibody generation and cytokine secretion. Besides, γδ T lymphocytes, Th17 cells, interleukin (IL)-4 and IL-10 also function in different stages of RA. This paper discusses the correlation of cells, antibodies and cytokines with the development, diagnosis and treatment of RA.

Key words: rheumatoid arthritis, autoimmune disease, T lymphocyte, B lymphocyte, autoantibody