上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (7): 1041-.doi: 10.3969/j.issn.1674-8115.2011.07.038

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甲状旁腺肿瘤及增生的临床病理学研究进展

胡 娜, 金晓龙   

  1. 上海交通大学 医学院附属瑞金医院病理科, 上海 200025
  • 出版日期:2011-07-28 发布日期:2011-07-27
  • 通讯作者: 金晓龙, 电子信箱: xljin8@yahoo.com。
  • 作者简介:胡 娜（1986—）, 女, 硕士生；电子信箱: hu5043039003@yahoo.com.cn。

Research progress of clinicopathology of parathyroid tumors and hyperplasia

HU Na, JIN Xiao-long   

  1. Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2011-07-28 Published:2011-07-27

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摘要：

组织病理学检查能确定甲状旁腺亢进症的病理类型，是鉴别甲状旁腺增生、甲状旁腺腺瘤和甲状旁腺癌的经典方法。近年来, 甲状旁腺肿瘤及增生的免疫组织化学标记、分子病理学研究进展迅速，研究包括Cyclin D1, MEN1, HRPT2和CaSR基因与蛋白。临床影像学技术的发展使甲状旁腺疾病的术前诊断更为准确，术中测定的甲状旁腺激素水平可作为评估手术疗效的指标。

关键词: 甲状旁腺功能亢进, 甲状旁腺肿瘤, 甲状旁腺增生, 病理学

Abstract:

Histopathological examination can determine the pathological types of hyperparathyroidism, which is a classical method to differentiate among parathyroid hyperplasia, parathyroid adenoma and parathyroid carcinoma. In recent years, there has been rapid progress in research of immunohistochemical labelling and molecular pathology of parathyroid tumors and hyperplasia, including Cyclin D1, MEN1, HRPT2 and CaSR gene and protein. The development of clinical imaging techniques makes the preoperative diagnosis of parathyroid diseases more accurate, and the parathyroid hormone levels measured during operation may serve as parameters for evaluation of surgical outcomes.

Key words: hyperparathyroidism, parathyroid tumor, parathyroid hyperplasia, pathology