上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (12): 1636-.doi: 10.3969/j.issn.1674-8115.2012.12.024

• 综述 • 上一篇    下一篇

血清微小RNA在肺癌诊断及预后评估中的作用

王 琳, 薛 剑, 娄加陶   

  1. 上海交通大学附属胸科医院检验科, 上海 200030
  • 出版日期:2012-12-28 发布日期:2012-12-31
  • 通讯作者: 娄加陶, 电子信箱: jiatao1001@yahoo.com.cn。
  • 作者简介:王 琳（1988—）, 女, 硕士生；电子信箱: linwangssmu@163.com。
  • 基金资助:

    上海市科委医学重点项目（10411950600）

Roles of serum microRNA in diagnosis and prognostic evaluation of lung cancer

WANG Lin, XUE Jian, LOU Jia-tao   

  1. Department of Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China
  • Online:2012-12-28 Published:2012-12-31
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 10411950600

PDF (PC)

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摘要：

肺癌是世界范围内引起癌症相关死亡的首要原因。寻找能够进行早期检测、预测转移和预后以及侵入性小的方法对于提高肺癌患者生存率有重要作用。微小RNA(miRNA）是一类非编码小RNA分子，通过与目标mRNA序列互补配对导致翻译抑制和（或）mRNA降解。miRNA在肿瘤的发生和发展过程中起着重要作用，包括肺癌在内的很多恶性肿瘤中都可以发现miRNA的表达失调。最近研究表明，miRNA不仅可以在石蜡包埋组织和体液中保持稳定，而且在血清和血浆中也可以稳定存在，这个特性使循环miRNA有望成为一种新型分子标志物，为肺癌的早期分子诊断、预测转移及预后开辟了一个新的研究领域。

关键词: 微小RNA, 血清, 肺癌, 诊断, 转移, 预后

Abstract:

Lung cancer is one of the leading causes of cancer-related death in the world. Developing minimally invasive techniques that can detect lung cancer, particularly at an early stage, as well as predict metastasis and prognosis, is an important strategy to improve the outcome. MicroRNA (miRNA) are a class of small non-coding RNA species that play important roles in tumorigenesis and tumor development by binding to their target mRNAs and inducing translation inhibition and/or mRNA degradation. Dysregulation of miRNAs is frequently found in malignancies, including lung cancer. Recent studies have revealed that miRNA are not only stable in paraffin-embedded tissues and body fluids, but also in plasma and serum, which makes circulating miRNA a new kind of ideal biomarker that opens a new field for early molecular diagnosis of lung cancer, as well as for prediction of lung cancer metastasis and survival.

Key words: microRNA, serum, lung cancer, diagnosis, metastasis, prognosis