上海交通大学学报（医学版）

›› 2013, Vol. 33 ›› Issue (5): 681-.doi: 10.3969/j.issn.1674-8115.2013.05.035

• 综述 • 上一篇    下一篇

自然杀伤细胞介导的固有免疫在慢性丙型肝炎病毒感染中的作用

方 艳, Sandeepkumarkarn, 张大志   

  1. 重庆医科大学附属第二医院感染病科, 重庆 400010
  • 出版日期:2013-05-28 发布日期:2013-05-28
  • 通讯作者: 张大志, 电子信箱: zhangdazhi_1014@163.com。
  • 作者简介:方 艳（1981—）, 女, 住院医师, 硕士； 电子信箱: 47222759@qq.com。

Role of innate immunity mediated by natural killer cells in chronic hepatitis C virus infection

FANG Yan, Sandeepkumarkarn, ZHANG Da-zhi   

  1. Department of Infection, the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
  • Online:2013-05-28 Published:2013-05-28

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摘要：

丙型肝炎病毒（HCV）是导致慢性肝病的重要病原体。固有免疫在慢性丙型肝炎的致病机制中发挥了重要作用。自然杀伤（NK）细胞在肝脏中含量丰富，其在慢性HCV感染中介导的固有免疫反应是近年来研究的热点之一。文章对近年来在慢性HCV感染中NK细胞介导的抗病毒固有免疫反应方面的研究进行了综述。

关键词: 丙型肝炎病毒, 自然杀伤细胞, 固有免疫

Abstract:

Hepatitis C virus is the important pathogen of chronic liver diseases. The innate immunity plays a vital role in the pathogenesis of chronic hepatitis C. Natural killer cells, abundant in liver, mediate innate immunological response, which has been one of the hotspots in the researches in recent years. The research progress of innate immunological response mediated by natural killer cells in chronic hepatitis C infection is reviewed in this paper.

Key words: hepatitis C virus, natural killer cell, innate immunity