上海交通大学学报（医学版）

上海交通大学学报（医学版）

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巨噬细胞与胶质瘤关系的研究进展

谢宝树，江基尧，殷玉华   

  1. 上海交通大学 医学院附属仁济医院神经外科， 上海 200127
  • 出版日期:2014-07-28 发布日期:2014-08-11
  • 作者简介:谢宝树（1990—）， 男， 硕士生; 电子信箱: xbshu21@sina.com。

Advances of relationship between macrophages and glioma

XIE Bao-shu, JIANG Ji-yao, YIN Yu-hua   

  1. Department of Neurosurgery， Renji Hospital， Shanghai Jiao Tong University School of Medicine， Shanghai 200127， China
  • Online:2014-07-28 Published:2014-08-11

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摘要：

巨噬细胞（在大脑中主要是小胶质细胞）作为一线的免疫细胞具有极大的可塑性。肿瘤相关巨噬细胞（小胶质/巨噬细胞）在胶质瘤的发生和发展中的作用具有两面性，既可在胶质瘤微环境中受胶质瘤分泌细胞因子的调控而促进肿瘤的生长及侵袭，也可以在人为影响下成为杀伤肿瘤的一员。小胶质/巨噬细胞能够通过血脑屏障，改变胶质瘤微环境使其表现为抑制胶质瘤生长与侵袭，将为恶性胶质瘤的治疗提供新的方向。

关键词: 巨噬细胞, 胶质瘤, 可塑性, 侵袭

Abstract:

As front line immune cells, macrophages (predominant microgial cells in the brain) have great plasticity. Macrophages relevant to tumor (microgial cells/macrophages) have double effects on the occurrence and development of glioma, i.e. promoting the development and invasion of the tumor in glioma microenvironment under the regulation of cytokines secreted by glioma or killing tumor cells under the influence of human. Microgial cells/macrophages can cross the blood-brain barrier; change the glioma microenvironment; and inhibit the development and invasion of glioma. It is a new way for the treatment of malignant glioma.

Key words: macrophages, glioma, plasticity, invasion