上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 综述 • 上一篇    下一篇

sclerostin在骨代谢中的作用和机制

张爽，高艳虹   

  1. 上海交通大学 医学院附属新华医院老年医学科， 上海 200092
  • 出版日期:2015-04-28 发布日期:2015-04-29
  • 通讯作者: 高艳虹, 电子信箱: yhgao2010@yahoo.com。
  • 作者简介:张爽(1989—)， 女， 硕士生; 电子信箱: shuangdd@sina.com。
  • 基金资助:

    国家自然科学基金(81101360); 上海市科委科研创新项目(12YZ053)

Effects and mechanisms of sclerostin in bone metabolism

ZHANG Shuang, GAO Yan-hong   

  1. Department of Geriatrics， Xinhua Hospital， Shanghai Jiaotong University School of Medicine， Shanghai 200092， China
  • Online:2015-04-28 Published:2015-04-29
  • Supported by:

    National Natural Science Foundation of China， 81101360； Innovation Project of Science and Technology Commission of Shanghai Municipality， 12YZ053

PDF (PC)

1384

摘要：

sclerostin是由SOST编码的糖蛋白，可以通过与Lrp4/5/6受体结合抑制Wnt信号通路,发挥调节骨代谢的作用。硬化性骨病、Van Buchem病、颅骨骨干发育异常等染色体异常性疾病及骨质疏松症均与SOST基因突变有关。近年来研究证实sclerostin不仅可以通过多种途径阻碍成骨细胞分化而发挥抑制骨形成的作用，还可以通过促进破骨细胞生成和依赖RANKL的方式激活破骨细胞功能促进骨吸收。sclerostin单克隆抗体为骨质疏松症的治疗提供了新的途径，目前正在进行临床试验，其有效性及安全性需要进一步研究。

关键词: sclerostin, 骨代谢, Wnt信号通路, 骨质疏松

Abstract:

Sclerostin is a glycoprotein encoding by SOST gene and can bind to Lrp4/5/6 receptor to block the Wnt signaling pathway, so as to regulate the bone metabolism. Mutations of the SOST gene are relevant to osterporosis and autosomal dominant diseases such as sclerosteosis, Van Buchem disease, and craniodiaphyseal dysplasia. Recent studies have confirmed that sclerostin can not only block the differentiation of osteoblast to inhibit bone formation by various ways, but also have a catabolic action through promotion of osteoclast formation and activation of osteocytes in a RANKL-dependent manner. The sclerostin monoclonal antibody may bring a new way for the treatment of osteoporosis. Currently, the clinical test is underway. The safety and validity of sclerostin monoclonal antibody need to be further researched.

Key words: sclerostin, bone metabolism, Wnt signaling pathway, osteoporosis