上海交通大学学报（医学版）

上海交通大学学报（医学版）

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转录因子AP-2与胚胎发育及心脏血管发育研究进展

王静，李奋   

  1. 上海交通大学 医学院附属上海儿童医学中心心内科，上海 200127
  • 出版日期:2016-11-28 发布日期:2016-11-29
  • 通讯作者: 李奋，电子信箱：lifen_88@aliyun.com。
  • 作者简介:王静（1983—），女，住院医师，硕士；电子信箱：tie119@126.com。
  • 基金资助:

    国家自然科学基金（81170152）

Research advances in transcription factor AP-2 in embryonic and cardiovascular development
 

WANG Jing, LI Fen   

  1. Department of Pediatric Cardiology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2016-11-28 Published:2016-11-29
  • Supported by:

    National Natural Science Foundation of China, 81170152

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摘要：

转录因子AP-2家族在胚胎发育及心脏血管发育过程中均发挥着重要作用，常导致胚胎发育受阻。心脏血管发育主要与AP-2α及AP-2β两者相关，其中AP-2α主要作用于心室流出道及大动脉，而AP-2β被证实与心脏动脉导管的开放与闭合机制有关。该文系统综述了AP-2基因家族的结构、表达、在胚胎发育及心脏血管发育中的功能与途径，尤其是在动脉导管未闭发生中的最新研究进展。

关键词: 转录因子, 胚胎发育, 心脏血管发育, 动脉导管

Abstract:

Transcription factor AP-2 plays an important role in embryonic and cardiovascular development and often influences the development of embryo. AP-2α and AP-2β are associated with the development of cardiovascular system. AP-2α mainly affects ventricular outflow tract and arteries, while AP-2β has been identified to be involved in the opening and closing of ductus arterious. This paper systematically reviews latest research advances in the structure and expression of AP-2 gene family, as well as its functions and mechanisms in embryonic and cardiovascular development, especially in patent ductus arterious.

Key words: transcription factor, embryonic development, cardiovascular development, ductus arterious