上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

硬化参数β结合颈动脉内中膜厚度预测动脉粥样硬化性脑卒中的作用

蔡叶华，王涌，王怡，陈莉   

  1. 复旦大学附属华山医院超声医学科，上海 200040
  • 出版日期:2017-05-28 发布日期:2017-05-31
  • 作者简介:蔡叶华（1980—），男，主治医师，硕士；电子信箱：sunnei@msn.com。

Effect of stiffness parameter β combined with carotid intima-media thickness on predicting ischemic stroke

CAI Ye-hua, WANG Yong, WANG Yi, CHEN Li   

  1. Department of Medical Ultrasound, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Online:2017-05-28 Published:2017-05-31

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摘要：

目的 ·探索硬化参数β联合颈动脉内中膜厚度（IMT）预测动脉粥样硬化性脑卒中的价值。方法 ·共99例急性动脉粥样硬化性脑卒中及短暂性脑缺血发作患者纳入研究，经常规颈动脉检查分为IMT增厚组及IMT无增厚组，分别与健康对照组比较其动脉硬化参数β；对IMT无增厚组病例按年龄分层，分别比较各年龄段患者与健康对照组间硬化参数β的差异。结果 · ① IMT增厚组及无增厚组硬化参数β明显高于健康对照组（均P=0.000）。② IMT无增厚组按年龄分层后，仅≥ 60岁年龄组患者的硬化参数β高于健康对照组（左侧P=0.047，右侧P=0.007）；而30～39岁、40～49岁及50～59岁年龄组硬化参数β与健康对照组比较，差异均无统计学意义。结论 ·在≥ 60岁具有动脉粥样硬化危险因子但无颈动脉IMT增厚及斑块的人群中，IMT结合硬化参数β可提高其预测能力。

关键词: 动脉粥样硬化, 脑卒中, 血管回声跟踪技术, 硬化参数, 内中膜厚度

Abstract:

Objective · To explore whether stiffness parameter β could help carotid intima-media thickness (IMT) to predict ischemic stroke. Methods · Ninety-nine patients with acute ischemic stroke and transient ischemic attacks were retrospectively evaluated by routine ultrasound and divided into increased IMT group and normal IMT group. The normal IMT group cases were further divided into 30～39 years, 40～49 years, 50～59 years and ≥60 years groups, and were compared with healthy crowd respectively. Results · ① The common carotid artery wall β of both increased IMT group and normal IMT group were significantly higher than healthy crowd (each P=0.000). ② Further analysis showed that β of ≥ 60 years group were significantly higher than healthy crowd (left side P=0.047, right side P=0.007); while the difference was not found across younger age groups (30～39 years, 40～49 years and 50～59 years). Conclusion · Stiffness parameter β may help carotid intima-media IMT to predict ischemic stroke in high risk subjects ≥ 60 years old without morphology changes.

Key words: atherosclerosis, ischemic stroke, echo-tracking, stiffness parameter, intima-media thickness