上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (6): 680-.doi: 10.3969/j.issn.1674-8115.2018.06.017

• 综述 • 上一篇    下一篇

功能性近红外光谱在精神分裂症诊治中的应用

魏燕燕1，张天宏1，唐云翔2，唐晓晨1，徐丽华1，王继军1   

  1. 1. 上海交通大学医学院附属上海市精神卫生中心，上海200030；2. 第二军医大学心理与精神卫生学系精神医学心理学教研室，上海200433
  • 出版日期:2018-06-28 发布日期:2018-07-03
  • 通讯作者: 王继军，电子信箱：jijunwang27@163.com。
  • 作者简介:魏燕燕（1986—），女，研究实习员，硕士；电子信箱：weiyanyan19860729@126.com。
  • 基金资助:
    国家自然科学基金（81671329，81372122）；上海市卫生和计划生育委员会科研课题（20174Y0013）；上海市科学技术委员会课题（16JC1420200）；上海交通大学医工交叉项目（YG2016QN42）；上海交通大学医学院协同创新中心项目（W35协同）

Application of functional near-infrared spectroscopy in schizophrenia

WEI Yan-yan1, ZHANG Tian-hong1, TANG Yun-xiang2, TANG Xiao-chen1, XU Li-hua1, WANG Ji-jun1   

  1. 1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Department of Psychiatry, Faculty of Mental Health, Second Military Medical University, Shanghai 200433, China
  • Online:2018-06-28 Published:2018-07-03
  • Supported by:
    National Natural Science Foundation of China, 81671329,81372122; Shanghai Municipal Health and Family Planning Comission Research Project, 20174Y0013; Shanghai Science and Technology Committee Project, 16JC1420200;Shanghai Jiao Tong University Medical-Engineering Crossing Project, YG2016QN42; Collaborative Innovation Project of Shanghai Jiao Tong University School of Medicine, W35 collaboration

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摘要： 功能性近红外光谱（functional near-infrared spectroscopy，fNIRS）是一项相对较新的技术，利用血红蛋白对不同波长红外光的吸收率不同，从而测量大脑组织内血红蛋白浓度的相对变化，获取大脑血流动力学特征，以实时了解大脑的功能状态。相对于其他功能影像技术，fNIRS具有相对的优势，因此在精神科的应用进展迅速。精神分裂症是精神疾病中最常见的一类，目前对其病因的研究主要集中在脑结构和功能改变的神经生物学机制，而现有的研究技术仅能提供一些间接的证据，fNIRS则可以实时进行脑功能监测，因此近来大量的研究提议fNIRS信号可以作为精神分裂症识别和辅助诊断的生物标记。现就fNIRS在精神分裂症诊治中的应用研究进行综述。

关键词: 功能性近红外光谱, 氧和血红蛋白, 脱氧血红蛋白, 精神分裂症, 生物标记

Abstract:

Functional near-infrared spectroscopy (fNIRS) is a relatively new technique that can measure the hemoglobin changes in brain tissue. Depending on the absorption for different wavelength, relative changes in the concentration of hemoglobin in brain can be measured, obtaining the hemodynamic characteristics of brain to understand the brain functional state in real-time. Compared with other neuroimaging techniques, it has some advantages and has been used in psychiatry rapidly. Schizophrenia is one of the most common mental disorders, researches on its pathogenesis have focused on collection of structural and functional alteration in brain. Existing techniques can provide only indirect evidence, while fNIRS can perform brain function monitoring in real-time. A number of studies have suggested that fNIRS signal could be used as a biomarker for schizophrenia identification and adjuvant diagnosis. This paper reviewed the research progress in the application of fNIRS in schizophrenia.

Key words: functional near-infrared spectroscopy, oxygen-hemoglobin, deoxygen- hemoglobin, schizophrenia, biomarker

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