上海交通大学学报(医学版) ›› 2021, Vol. 41 ›› Issue (5): 653-658.doi: 10.3969/j.issn.1674-8115.2021.05.016

• 综述 • 上一篇    下一篇

冻融胚胎移植对子代的近、远期影响

秦宁馨1,2(), 赵文龙1,2, 周志阳1,2, 施炜慧1,2, 吴琰婷1,2,3, 黄荷凤1,2,3()   

  1. 1.上海交通大学医学院附属国际和平妇幼保健院胚胎源性疾病研究所,上海 200030
    2.上海市胚胎源性疾病重点实验室,上海 200030
    3.复旦大学生殖与发育研究院,上海 200032
  • 出版日期:2021-05-28 发布日期:2021-05-27
  • 通讯作者: 黄荷凤 E-mail:qinningxin@sjtu.edu.cn;huanghefg@sjtu.edu.cn
  • 作者简介:秦宁馨(1991—),女,博士生;电子信箱:qinningxin@sjtu.edu.cn
  • 基金资助:
    国家重点研发计划(2017YFC1001300);国家自然科学基金(81661128010)

Short- and long-term effects of frozen-thawed embryo transfer on offspring

Ning-xin QIN1,2(), Wen-long ZHAO1,2, Zhi-yang ZHOU1,2, Wei-hui SHI1,2, Yan-ting WU1,2,3, He-feng HUANG1,2,3()   

  1. 1.Institute of Embryo Original Diseases, the International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
    2.Shanghai Key Laboratory of Embryo Original Diseases, Shanghai 200030, China
    3.Institute of Reproductive and Developmental Research, Fudan University, Shanghai 200032, China
  • Online:2021-05-28 Published:2021-05-27
  • Contact: He-feng HUANG E-mail:qinningxin@sjtu.edu.cn;huanghefg@sjtu.edu.cn
  • Supported by:
    National Key R&D Program of China(2017YFC1001300);National Natural Science Foundation of China(81661128010)

摘要:

冻融胚胎移植(frozen-thawed embryo transfer,FET)是常用辅助生殖技术之一。由于FET具有累积妊娠率高、卵巢过度刺激综合征发生率低等优势,通过该项技术出生的子代数量逐年增加。多项研究提示FET子代发生围产期早产、低出生体质量、小于胎龄儿等的风险低于新鲜胚胎移植周期出生的子代,也有证据显示FET子代出现巨大儿、大于胎龄儿等的风险较高;同时,亦有研究针对FET子代在儿童期及成人期的长期健康状况进行报道。该文就FET对子代的近、远期影响及其原因进行综述。

关键词: 辅助生殖技术, 冻融胚胎移植, 子代, 近期影响, 远期影响

Abstract:

Frozen-thawed embryo transfer (FET) is one of the commonly used assisted reproductive technology. Because FET has the advantages of high cumulative pregnancy rate and low incidence of ovarian hyperstimulation syndrome, the number of offspring born through this technology is increasing year by year. Many studies have shown that the risks of preterm delivery, low birth weight and small for gestation age of FET offspring are lower than those of the offspring born in the fresh embryo transfer cycle. There is also evidence that the risks of macrosomia and large for gestational age of FET offspring are higher. At the same time, there are also reports on the long-term health status of FET offspring in childhood and adulthood. This paper reviews the short-term and long-term effects of FET on offspring and the causes.

Key words: assisted reproductive technology (ART), frozen-thawed embryo transfer (FET), offspring, short-term effect, long-term effect

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