胶原蛋白在肿瘤发生和发展中的作用综述

doi:10.3969/j.issn.1674-8115.2023.12.014

上海交通大学学报（医学版） ›› 2023, Vol. 43 ›› Issue (12): 1577-1584.doi: 10.3969/j.issn.1674-8115.2023.12.014

• 综述 • 上一篇

胶原蛋白在肿瘤发生和发展中的作用综述

唐雷¹(), 徐迎春²(), 张凤春¹^,³()

^1.上海交通大学医学院苏州九龙医院肿瘤科，苏州 215021
^2.上海交通大学医学院附属仁济医院肿瘤科，上海 200126
^3.上海交通大学医学院附属瑞金医院肿瘤科，上海 200025

收稿日期:2023-06-01 接受日期:2023-10-27 出版日期:2023-12-28 发布日期:2024-02-01
通讯作者: 徐迎春,张凤春 E-mail:bobbytang_1982@126.com;xiaoxu2384@163.com;fczhang2004@163.com
作者简介:唐雷（1982—），男，主治医师，博士；电子信箱：bobbytang_1982@126.com。
基金资助:
2023年苏州市姑苏卫生人才计划;2023年度苏州市基础研究计划(SKY2023110);2022年度苏州市科技计划项目(SKYD2022083);2020年度苏州市科技发展计划项目(SYSD2020079)

Review of the role of collagen in tumorigenesis and development

TANG Lei¹(), XU Yingchun²(), ZHANG Fengchun¹^,³()

^1.Department of Oncology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou 215021, China
^2.Department of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200126, China
^3.Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received:2023-06-01 Accepted:2023-10-27 Online:2023-12-28 Published:2024-02-01
Contact: XU Yingchun,ZHANG Fengchun E-mail:bobbytang_1982@126.com;xiaoxu2384@163.com;fczhang2004@163.com
Supported by:
2023 Gusu Talent Program;2023 Suzhou Basic Research Plan（Medical Application Basic Research, SKY2023110);2022 Suzhou Science and Technology Plan Project(SKYD2022083);2020 Suzhou Science and Technology Development Plan Project(SYSD2020079)

摘要/Abstract

摘要：

胶原蛋白是人体含量最丰富的蛋白质之一，是细胞外基质的主要成分。胶原蛋白可以调节细胞行为，胶原蛋白表达失调可导致多种疾病，包括肿瘤。肿瘤中胶原蛋白主要由成纤维细胞产生，在肿瘤进展和转移中发挥重要作用。胶原蛋白作为肿瘤患者预后的预测因子，可能是有效治疗及预防肿瘤进展及转移的靶点，将来可能会研发出针对胶原蛋白及其受体的抗肿瘤药物。该文综述近年来新发现的胶原蛋白在肿瘤发生和发展中的作用，特别是胶原蛋白在维持肿瘤细胞休眠状态和免疫逃逸中的作用，以及胶原蛋白如何参与肿瘤细胞代谢。

关键词: 胶原蛋白, 细胞外基质, 癌症进展, 肿瘤转移, 免疫逃逸

Abstract:

Collagen is one of the most abundant proteins in the body and is the main component of the extracellular matrix. Collagen regulates cellular behavior, and its dysregulation can cause a variety of diseases, including cancer. Collagen in tumors is mainly produced by fibroblasts and plays an important role in cancer progression and metastasis. Collagen can act as a prognostic predictor for cancer patients and may be an effective target for the treatment and prevention of tumor progression and metastasis. Anti-tumor drugs targeting collagen and its receptors may be developed in the future. This review focuses on the newly discovered role of collagen in cancer in recent years, specifically the role of collagen in tumor cell dormancy and immune evasion, and the participation of collagen in tumor cell metabolism.

Key words: collagen, extracellular matrix, cancer progression, tumor metastasis, immune escape

中图分类号:

R730.2

唐雷, 徐迎春, 张凤春. 胶原蛋白在肿瘤发生和发展中的作用综述[J]. 上海交通大学学报（医学版）, 2023, 43(12): 1577-1584.

TANG Lei, XU Yingchun, ZHANG Fengchun. Review of the role of collagen in tumorigenesis and development[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(12): 1577-1584.

图/表 1

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Receptor	Cell type	Collagen type
Integrin α1β1	Mesenchymal cells, inflammatory cells (T lymphocytes), epithelial cells, platelets	Collagen Ⅳ and Ⅵ, fibril-forming collagens
Integrin α2β1	Mesenchymal cells, epithelial cells, platelets	Fibril-forming collagens
Integrin α10β1	Chondrocytes	Collagen Ⅳ and Ⅵ
Integrin α11β1	Mesenchymal cells	Fibril-forming collagens and collagen Ⅹ
DDR1	Epithelial cells	Fibril-forming collagens (Collagen Ⅰ, Ⅱ, Ⅲ), Collagen Ⅳ and Ⅷ
DDR2	Mesenchymal cells	Fibril-forming collagens and collagen Ⅹ
GPVI	Platelets	Fibril-forming collagens
LAIR-1, LAIR-2	Leukocytes	Collagen I, transmembrane collagens 􀃼, ⅩⅦ, Ⅹ􀃼
OSCAR	Vascular endothelial cells, osteoclast, macrophages	Fibril-forming collagens (Collagen Ⅰ, Ⅱ, Ⅲ)
GPR56	Platelets	Fibril-forming collagens (i.e., Collagen Ⅲ)
Mannose receptor family (MR, PLA2R, DEC-205, Endo180)	Fibroblasts	Fibril-forming collagens and collagen Ⅳ

Receptor	Cell type	Collagen type
Integrin α1β1	Mesenchymal cells, inflammatory cells (T lymphocytes), epithelial cells, platelets	Collagen Ⅳ and Ⅵ, fibril-forming collagens
Integrin α2β1	Mesenchymal cells, epithelial cells, platelets	Fibril-forming collagens
Integrin α10β1	Chondrocytes	Collagen Ⅳ and Ⅵ
Integrin α11β1	Mesenchymal cells	Fibril-forming collagens and collagen Ⅹ
DDR1	Epithelial cells	Fibril-forming collagens (Collagen Ⅰ, Ⅱ, Ⅲ), Collagen Ⅳ and Ⅷ
DDR2	Mesenchymal cells	Fibril-forming collagens and collagen Ⅹ
GPVI	Platelets	Fibril-forming collagens
LAIR-1, LAIR-2	Leukocytes	Collagen I, transmembrane collagens 􀃼, ⅩⅦ, Ⅹ􀃼
OSCAR	Vascular endothelial cells, osteoclast, macrophages	Fibril-forming collagens (Collagen Ⅰ, Ⅱ, Ⅲ)
GPR56	Platelets	Fibril-forming collagens (i.e., Collagen Ⅲ)
Mannose receptor family (MR, PLA2R, DEC-205, Endo180)	Fibroblasts	Fibril-forming collagens and collagen Ⅳ

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[15]	史浩骏，王志刚. 长链非编码RNA肺腺癌转移相关转录本1及其在肿瘤转移中的作用[J]. 上海交通大学学报（医学版）, 2014, 34(8): 1254-.

胶原蛋白在肿瘤发生和发展中的作用综述

Review of the role of collagen in tumorigenesis and development

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