上海交通大学学报(医学版)

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趋化因子CCL7的研究进展

胡庆翔1,戚文潇1,章雪飞1,朱佳芳1,金泽宇1,程 枫2   

  1. 上海交通大学 1. 医学院临床医学系, 2.基础医学院教学实验中心, 上海 200025
  • 出版日期:2013-07-28 发布日期:2013-08-22
  • 通讯作者: 程枫, 电子信箱: jychengf@shsmu.edu.cn。
  • 作者简介:胡庆翔(1991—),男,2010级临床医学八年制学生; 电子信箱: heathcliff@sjtu.edu.cn。
  • 基金资助:

    上海市大学生创新性实验计划(2012020)

Research progress of CCL7

HU Qing-xiang1, QI Wen-xiao1, ZHANG Xue-fei1, ZHU Jia-fang1, JIN Ze-yu1, CHENG Feng2   

  1. 1.School of Clinical Medicine, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China; 2.Experiment Teaching Center, Basic Medical College,
    Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2013-07-28 Published:2013-08-22
  • Supported by:

    Shanghai College Student Innovation Research Program, 2012020

摘要:

CC趋化因子7 (CCL7)主要在成纤维细胞、单核细胞、肿瘤细胞中表达,于内质网中修饰成熟后分泌至胞外,其受体有CCR1、CCR2、CCR3等,在募集单核细胞、引发钙离子内流、肿瘤转移等生物效应中起重要作用。文章就CCL7基因结构、分子及前体、生理功能、CCL7与疾病关系等进行综述。

关键词: CC趋化因子7, 基因, 分子结构, 肿瘤

Abstract:

Chemokine (C-C motif) ligand 7 (CCL7) is widely expressed in fibroblasts, monocytes and tumor cells, and exerts a spectrum of functions as monocyte recruitment, elicitation of calcium influx and facilitation of tumor metastasis via its interaction with specific receptors of CCR1, CCR2 and CCR3. This review will represent the up-to-date findings of CCL7 on its genetic and molecular structure, physiologic function, and its correlation with diseases.

Key words: chemokine (C-C motif) ligand 7, gene, molecular structure, tumor