上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（基础研究） • 上一篇    下一篇

主动脉峡部环扎构建猪导管前型主动脉缩窄模型

李继军1，王 斐1，朱丽敏2，孙彦隽2   

  1. 1.新疆维吾尔自治区喀什地区第二人民医院心胸外科， 喀什 844000； 2.上海交通大学医学院附属上海儿童医学中心心胸外科， 上海 200127
  • 出版日期:2014-01-28 发布日期:2014-01-29
  • 通讯作者: 孙彦隽, 电子信箱: osirosir@hotmail.com。
  • 作者简介:李继军（1971—）， 男， 副主任医师， 学士; 电子信箱: 1256239505@qq.com。

Establishment of porcine model of pre-ductus coarctation of aorta by aortic isthmus banding

LI Ji-jun1, WANG Fei1, ZHU Li-min2, SUN Yan-jun2   

  1. 1.Department of Cardiothoracic Surgery, the Second People′s Hospital, Kashi Prefecture, Xinjiang Uygur Autonomous Region, Kashi 844000, China; 2.Department of Cardiothoracic Surgery, Shanghai Children′s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2014-01-28 Published:2014-01-29

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摘要：

目的 建立主动脉峡部环扎构建猪导管前型主动脉缩窄模型。方法 将10头猪麻醉后，经左侧第三肋间开胸，使用聚对二氧环己酮单丝可吸收缝线环绕主动脉峡部，固定其直径，测定主动脉峡部直径及跨主动脉峡部的收缩压差值（ΔP）。8周后，行心导管介入术，再次测定主动脉峡部直径及ΔP，用球囊导管对主动脉峡部进行扩张。结果 8周后，2头动物主动脉峡部直径增大，未测得ΔP；建模成功率为80%。建模成功的8头动物，在心导管介入术时的体质量明显高于建模前，差异有统计学意义（P<0.01）；球囊扩张术后的ΔP显著高于建模前，差异有统计学意义（P<0.01）；但球囊扩张术后主动脉峡部内径无明显增大，差异无统计学意义（P>0.05）。结论 成功建立了主动脉峡部环扎构建猪导管前型主动脉缩窄模型的方法。

关键词: 主动脉缩窄, 动物模型, 猪, 主动脉峡部, 环扎

Abstract:

Objective To establish the porcine model of pre-ductus coarctation of aorta by aortic isthmus banding. Methods Ten piglets were under anesthesia, then the aortic isthmus was exposed via left thoracotomy of third intercostals space, and circled by polydiaxanone absorbable monofilament suture to fix its size. The diameter of aortic isthmus and systolic pressure gradient across aortic isthmus (ΔP) were measured. After 8 weeks, cardiac catheterization procedure was performed, and the diameter and ΔP were remeasured. The aortic isthmus was dilated with balloon catheter. Results Eight weeks later, in 2 piglets, diameter of aortic isthmus increased and ΔP was not detected. So the success rate of modeling was 80%. By cardiac catheterization, the other 8 piglets of successful modeling had gained weight (P<0.01). After balloon dilation, the values of ΔP were higher than those before modeling (P<0.01), but diameters of aortic isthmus did not significantly increase (P>0.05). Conclusion The approach for porcine model of pre-ductus coarctation of aorta by aortic isthmus banding has been successfully established.

Key words: coarctation of aorta, animal model, porcine, aortic isthmus, banding