上海交通大学学报（医学版）

上海交通大学学报（医学版）

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转录因子CCAAT增强子结合蛋白α的研究进展

应 霁，王伟铭   

  1. 上海交通大学 医学院附属瑞金医院肾内科， 上海 200025
  • 出版日期:2015-02-28 发布日期:2015-02-27
  • 通讯作者: 王伟铭, 电子信箱: wweiming01@126.com。
  • 作者简介:应 霁（1990—）， 女， 硕士生; 电子信箱: yingji1990@sina.cn。
  • 基金资助:

    国家自然科学基金(81270782, 30771000)；国家重点基础研究发展计划(2012CB517701, 2012CB517604)；科技部十二五科技攻关项目(2011BAI10B00, 2011BAI10B06)；上海市卫计委重中之重学科建设项目，国家临床重点专科建设项目，卫生行业科研专项项目(201002010)

Research progresses of transcription factor CCAAT enhancer binding protein α

YING Ji, WANG Wei-ming   

  1. Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2015-02-28 Published:2015-02-27
  • Supported by:

    National Natural Science Foundation of China, 81270782, 30771000; National Basic Research Program of China, 2012CB517701, 2012CB517604; the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period, 2011BAI10B00, 2011BAI10B06; Key Discipline Construction Project of Shanghai Municipal Commission of Health and Family Planning; National Key Clinical Specialist Construction Program of China, Health Industry Special Research Project, 201002010

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摘要：

CCAAT增强子结合蛋白α（C/EBPα）是CCAAT增强子结合蛋白家族的一员。该家族属于碱性区亮氨酸拉链(bZIP)蛋白家族，在细胞增殖分化、细胞周期调控、免疫应答、炎症反应、能量代谢、肿瘤发生及凋亡等过程中发挥作用。文章就C/EBPα的结构、表达调控、生物学功能作一综述。

关键词: CCAAT增强子结合蛋白α, 结构, 表达调控, 生物学功能

Abstract:

CCAAT enhancer binding protein α (C/EBPα) is a member of CCAAT enhancer binding protein (C/EBP) family, which belongs to the basic region/zipper (bZIP) protein family. C/EBP family plays important roles in cell proliferation and differentiation, cell cycle regulation, immune responses, inflammatory reaction, energy metabolism, tumorigenesis, and tumor apoptosis. This paper reviews research progresses of the structure, expression regulation, and biology functions of C/EBPα.

Key words: CCAAT enhancer binding protein α, structure, expression regulation, biology function