上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

Musashi-1在子宫内膜腺癌中的表达及其评估预后的价值

丁文婧，马莉，滕银成，徐妍力   

  1. 上海交通大学附属第六人民医院妇产科， 上海 200233
  • 出版日期:2015-07-28 发布日期:2015-08-27
  • 作者简介:丁文婧(1988—)， 女， 博士生; 电子信箱: dwj71125@126.com。

Expression of Musashi-1 in endometrioid adenocarcinoma and its value for evaluating the prognosis

DING Wen-jing, MA Li, TENG Yin-cheng, XU Yan-li   

  1. Department of Obstetrics and Gynecology, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233， China
  • Online:2015-07-28 Published:2015-08-27

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摘要：

目的  评价Musashi-1在子宫内膜腺癌中的表达及其评估预后的价值。方法  采用real-time PCR检测35例子宫内膜腺癌组织和15例正常子宫内膜组织中Musashi-1 mRNA的表达。采用免疫组织化学法检测148例子宫内膜腺癌组织和20例正常子宫内膜组织中Musashi-1 蛋白的表达。分析Musashi-1表达与患者生存率的关系；与临床病理指标比较，评估Musashi-1在预测子宫内膜腺癌预后中的价值。结果  子宫内膜腺癌组织中Musashi-1 mRNA的表达明显高于正常子宫内膜组织(P<0.01)；Musashi-1表达与腺癌分期、分级和血管浸润相关（χ2=6.276，P<0.01；χ2=26.957，P<0.01；χ2=9.091，P<0.01）。Musashi-1阳性患者生存率显著低于阴性患者(HR=2.073, P<0.01)。结论  Musashi-1在子宫内膜腺癌中呈高表达，并与子宫内膜腺癌的预后呈负相关；Musashi-1可作为判断子宫内膜腺癌预后的独立指标，并有望成为肿瘤治疗的新靶点。

关键词: Musashi-1, 子宫内膜腺癌, 预后

Abstract:

Objective  To evaluate the expression of Musashi-1 in endometrioid adenocarcinoma (EAC) and its value for assessing the prognosis. Methods  The mRNA expressions of Musashi-1 of 35 EAC samples and 15 normal endometrium samples were detected by real-time PCR. The protein expressions of Musashi-1 of 148 EAC samples and 20 normal endometrium samples were detected by immunohistochemistry. The correlation between Musashi-1 expression and survival rate of patients was analyzed. The value of Musashi-1 expression for predicting the prognosis of EAC was evaluated according to clinicopathological indexes. Results  The mRNA expression of Musashi-1 of EAC tissues was significantly higher than that of normal endometrium tissues (P<0.01). Musashi-1 expression correlated with tumor stage, grade, and vascular invasion (χ2=6.276, P<0.01; χ2=26.957 P<0.01； χ2=9.091, P<0.01). The survival rate of patients with positive expression of Musashi-1 was significantly lower than that of patients with negative expression (HR=2.073, P<0.01). Conclusion  The Musashi-1 expression of EAC is high and negatively correlates with the prognosis of EAC. Musashi-1 can be used as an independent factor for predicting the prognosis of EAC and may be a new target for cancer treatment.

Key words: Musashi-1, endometrioid adenocarcinoma, prognosis