上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

肺癌18F-FDG PET/CT最大标准摄取值的相关因素研究

王少雁1，王辉1，左长京2，孙高峰2，陈素芸1，孔令山2   

  1. 1.上海交通大学 医学院附属新华医院核医学科， 上海 200092； 2.第二军医大学附属长海医院核医学科， 上海 200433
  • 出版日期:2015-07-28 发布日期:2015-08-27
  • 通讯作者: 王辉, 电子信箱: wanghuishanghai@hotmail.com。
  • 作者简介:王少雁（1978—）， 女， 主治医师, 硕士; 电子信箱: yanshaowang@126.com。
  • 基金资助:

     上海市科委基金（08411967800）

Study on relevant factors of maximum standard uptake value of 18F-FDG PET/CT for lung cancer

WANG Shao-yan1, WANG Hui1, ZUO Chang-jing2, SUN Gao-feng2,CHEN Su-yun1, KONG Ling-shan2   

  1. 1.Department of Nuclear Medicine， Xinhua Hospital, Shanghai Jiao Tong Universality School of Medicine， Shanghai 200092， China; 2.Department of Nuclear Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433， China
  • Online:2015-07-28 Published:2015-08-27
  • Supported by:

    Foundation of Science and Technology Commission of Shanghai Municipality， 08411967800

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摘要：

目的  探讨肺癌18F-FDG PET/CT的最大标准摄取值（SUVmax）与肺癌临床病理学特征的关系。方法  82例经病理证实为肺癌的患者于治疗前行18F-FDG PET/CT检查。采用感兴趣区（ROI）勾画技术测量病灶SUVmax。采用SPSS 11.5统计软件对SUVmax与患者性别、年龄及肿瘤直径（最大径）、病理类型、临床分期及分化程度等因素的关系进行统计学分析。结果  82例肺癌患者中，腺癌52例，鳞癌23例，小细胞癌7例。不同病理类型病灶的SUVmax大小依次为鳞癌>小细胞癌>腺癌，其中腺癌与鳞癌SUVmax的差异有统计学意义（P<0.05）； 在肿瘤最大径<3 cm组中，不同病理类型肿瘤SUVmax的差异具有统计学意义(F=18.5, P<0.01)；而在肿瘤最大径≥3 cm组中，不同病理类型肿瘤的SUVmax的差异无统计学意义（F=0.45，P=0.72）。Logistic多元线性回归分析结果显示：SUVmax与肿瘤最大径呈正相关，与肿瘤分化程度呈负相关；肿瘤直径和肿瘤分化程度对SUVmax存在多重共线性，校正直径因素后的回归模型显示分化程度为SUVmax的显著影响因素（β=0.618，t=7.52，P<0.05），而肿瘤分期及病理类型对SUVmax无显著影响。结论  肺癌病灶的SUVmax与肿瘤最大径和分化程度相关，且对SUVmax具有多重共线性，在多因素分析时校正直径因素的条件下，肿瘤分化程度为SUVmax的显著影响因素，而肿瘤分期和病理类型对SUVmax无显著影响。

关键词: 肺癌, 计算机断层扫描术, 正电子发射断层扫描, 18F-氟脱氧葡萄糖, 最大标准摄取值

Abstract:

Objective  To investigate the relationship between maximum standard uptake value（SUVmax)  and clinicopathological features of lung cancer with PET/CT scan. Methods  A total of 82 patients with lung cancer who were confirmed by pathology underwent 18F-FDG PET/CT before therapy. The SUVmax of the focus was measured and recorded by region of interest (ROI) technique. SPSS 11.5 was used to statistically analyze the relationship between SUVmax and clinical factors, including gender, age, diameter of tumor (maximum value), pathological type, clinical staging, differentiation, etc. Results  Among 82 cases of lung cancer, 52 were adenocarcinoma, 23 were squamous cell carcinoma, and 7 were small cell cancer. The descending order of SUVmax of different pathological types was that of squamous cell carcinoma, small cell carcinoma, and adenocarcinoma. The difference of SUVmax of squamous cell carcinoma and adenocarcinoma was statistically significant (P<0.05). Tumors were divided into ≥3 cm group and <3 cm group. The differences of SUVmax of different pathological types of the <3 cm group were statistically significant (F=18.5, P<0.01). The differences of SUVmax of different pathological types of the ≥3 cm group were not statistically significant (F=0.45，P=0.72). The results of multiple linear regression analysis showed the SUVmax positively correlated with the maximum diameter of tumor and negatively correlated with the differentiation of tumor. The differentiation and diameter of tumor were multicollinear with SUVmax. After the diameter factor was adjusted, the regression model showed that the differentiation of tumor was the significant influencing factor (β=0.618, t=7.52, P<0.05), while staging and pathological type did not significantly affect the SUVmax. Conclusion  The SUVmax of lung cancer focus is relevant to the maximum diameter and differentiation of tumor, which are multicollinear with SUVmax. After the diameter factor has been adjusted, multivariate analysis shows that the differentiation of tumor is the significant influencing factor of SUVmax, while staging and pathological type do not significantly affect the SUVmax.

Key words: lung cancer, tomography, emission-computed, 18F-deoxyglucose, maximum standard uptake value