上海交通大学学报(医学版) ›› 2015, Vol. 35 ›› Issue (10): 1585-.doi: 10.3969/j.issn.1674-8115.2015.10.031

• 综述 • 上一篇    下一篇

质子磁波谱技术对γ-氨基丁酸在精神分裂症中的研究进展

王俊杰,唐莺莹,王继军   

  1. 上海交通大学 医学院附属精神卫生中心脑电影像眼动研究室, 上海200030
  • 出版日期:2015-10-20 发布日期:2015-12-22
  • 通讯作者: 王继军, 电子信箱: jijunwang27@163.com
  • 作者简介:王俊杰(1978—), 女, 博士生; 电子信箱: wangjunjie6723@163.com
  • 基金资助:

    上海交通大学医学院脑疾病临床研究中心项目(20150626);上海市卫生系统先进适宜技术推广项目(2013SY003);上海市科委医学引导类项目(14411961400)

Advances of γ-aminobutyric acid of patients with schizophrenia by proton magnetic resonance spectroscopy

WANG Jun-jie, TANG Ying-ying, WANG Ji-jun   

  1. Department of EEG Source Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai200030, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    Project of Brain Diseases Clinical Research Center, Shanghai Jiao Tong University School of Medicine, 20150626; Shanghai Health System Advanced Appropriate Technology Promotion Project, 2013SY003; Medical Guide Project of Shanghai Science and Technology Commission, 14411961400

摘要:

精神分裂症是常见的重性精神疾病,且复发率和致残率高,但病因未明。γ-氨基丁酸(GABA)是脑内主要的抑制性神经递质,与精神分裂症的病理生理学机制有关。质子磁波谱技术可非侵入地在体直接定量检测患者大脑局部的GABA水平,为研究精神分裂症的病理机制以及开发新的干预措施提供了新途径。该文主要综述精神分裂症中采用质子磁波谱检测GABA的研究新进展。

关键词: 精神分裂症, 质子磁波谱, &gamma, -氨基丁酸

Abstract:

Schizophrenia is a common severe mental illness with high rate of relapse and disability, but the pathogenesis is unknown. Gama-aminobutyric acid (GABA) is the major inhibitory neurotransmitter, which is relevant to pathophysiological mechanisms of schizophrenia. Proton magnetic resonance spectroscopy is a non-invasive technique for directly measuring the regional GABA level of patient’s brain in vivo, which provides a novel idea for investigating the pathogenesis of schizophrenia and developing new intervention measures. This paper reviews progresses of studying GABA of patients with schizophrenia by proton magnetic resonance spectroscopy.

Key words: schizophrenia, proton magnetic resonance spectroscopy, γ-aminobutyric acid