上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

18F-FDG-PET/CT早期预测复发转移非小细胞肺癌的缓解率和生存期的临床研究

徐海燕1，许远帆2，闫宁宁1,3，陈彬1，徐迎春4，刘建军2,5，张凤春1,3   

  1. 上海交通大学 医学院 1.附属苏州九龙医院肿瘤科， 苏州 215021； 2.附属苏州九龙医院核医学科， 苏州 215021； 3.附属瑞金医院肿瘤学科, 上海 200025； 4.附属仁济医院肿瘤科, 上海 200127； 5.附属仁济医院核医学科, 上海 200127
  • 出版日期:2015-11-28 发布日期:2016-01-13
  • 通讯作者: 张凤春, 电子信箱: fczhang2004@163.com。
  • 作者简介:徐海燕(1979—)， 女， 主治医师， 硕士; 电子信箱: feelxu2001@163.com。
  • 基金资助:

    国家自然科学基金（81471687）；上海市卫生局科研基金（201440606）；国家卫计委科技发展项目（W2012FZ129）

Clinical study on the early prediction of the remission rate and survival of patients with recurrent metastatic NSCLC by 18F-FDG PET/CT

XU Hai-yan1, XU Yuan-fan2, YAN Ning-ning1,3, CHEN Bin1, XU Ying-chun4, LIU Jian-jun2,5, ZHANG Feng-chun1,3   

  1. 1.Department of Oncology, Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou 215021； 2.Department of Nuclear Medicine，Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou 215021； 3.Department of Oncology, Ruijin Hospital， Shanghai Jiao Tong University School of Medicine, Shanghai 200025； 4.Department of Oncology, Renji Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200127； 5.Department of Nuclear Medicine， Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127
  • Online:2015-11-28 Published:2016-01-13
  • Supported by:

    National Natural Science Foundation of China， 81471687； Scientific Research Foundation of Shanghai Municipal Health Bureau， 201440606； Science and Technology Development Project of National Health and Family Planning Commision of China， W2012FZ129

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摘要：

目的  研究18氟脱氧葡萄糖正电子发射成像/电子计算机断层扫描(18F-FDG-PET/CT)早期预测复发转移非小细胞肺癌（NSCLC）缓解率与生存期的应用价值。方法  选择复发转移NSCLC患者24例，于化疗前和化疗后第1周期内分别行18F-FDG PET/CT显像。分析缓解(OR)组与未缓解(non-OR)组之间SUVmax1、SUVmax2、ΔSUVmax、SUVmax变化率的差异及代谢反应对生存期(OS)的影响。结果  OR组患者的ΔSUVmax（2.415±0.266）显著高于non-OR组（0.854±0.316），P=0.001 7;OR组SUVmax变化率（31.320±0.723）显著高于non-OR组（9.909±3.592），P<0.001。生存分析显示OR组患者的生存期较non-OR组的患者明显延长（P＜0.05）；代谢反应组患者的OS显著优于代谢无反应组的患者（P＜0.05）；且代谢反应组缓解率76.92%，无代谢反应组缓解率0%（χ2=13.901, P＜0.001）。结论  18F-FDG PET/CT对复发转移NSCLC缓解率和生存期具有早期预测价值，仍需进一步临床研究验证。

关键词: PET/CT, 非小细胞肺癌, 代谢反应, 缓解率

Abstract:

Objective  To explore the application value of the 18F-FDG PET/CT for early prediction of the remission rate and survival of recurrent metastatic non-small cell lung cancer (NSCLC). Methods  A total of 24 patients with recurrent or metastatic NSCLC were selected. All patients underwent the PET/CT examination before and after the first cycle of chemotherapy. The differences of SUVmax1, SUVmax2, ΔSUVmax, and the change rate of SUVmax between the objective response (OR) group and non-objective response (non-OR) group were analyzed, as well as the effect of metabolic response on the overall survival (OS). Results  ΔSUVmax of the OR group (2.415±0.266) was significantly higher than that of the non-OR group (0.854±0.316, P=0.001 7). The change rate of SUVmax of the OR group (31.320±0.723) was remarkably higher than that of the non-OR group (9.909±3.592, P<0.001). The survival analysis showed that the overall survival of the OR group was obviously longer than that of the non-OR group (P<0.05). The overall survival of the metabolic response group was significantly longer than that of the non-metabolic response group (P<0.05). The remission response rates of the metabolic response group and non-metabolic response group were 76.92% and 0%, respectively (χ2=13.901, P<0.001). Conclusion  18F-FDG PET/CT is valuable for early prediction of the remission rate and survival of patients with recurrent or metastatic NSCLC and further clinical study and verification are needed.

Key words: PET/CT, NSCLC, metabolic response, response rate