上海交通大学学报（医学版）

上海交通大学学报（医学版）

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吸烟与糖尿病发生相关性的研究进展

邱婕萸真，侯旭宏，贾伟平   

  1. 上海交通大学附属第六人民医院内分泌代谢科 上海市糖尿病研究所 上海市糖尿病重点实验室  上海市糖尿病临床医学中心， 上海 200233
  • 出版日期:2016-01-28 发布日期:2016-02-26
  • 通讯作者: 贾伟平, 电子信箱: WPjia@sjtu.edu.cn。
  • 作者简介:邱婕萸真 （1989—）， 女， 博士生; 电子信箱: qjyz-8966@163.com。
  • 基金资助:

    国家高技术研究发展计划（863计划）（2015AA020105-05）

Research progresses of correlation between cigarette smoking andincidence of diabetes mellitus

QIU Jie-yu-zhen, HOU Xu-hong, JIA Wei-ping   

  1. Department of Endocrinology and Metabolism,  Shanghai Sixth Peoples Hospital, Shanghai Jiao Tong University, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai 200233, China
  • Online:2016-01-28 Published:2016-02-26
  • Supported by:

    National High Technology Research and Development Program of China，“863” Program， 2015AA020105-05。

PDF (PC)

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摘要：

近年来糖尿病的患病率快速上升，2013年全球糖尿病患病率达8.3%，我国糖尿病患病人数目前已居世界首位，约1.4亿。与此同时，全球吸烟人数约10亿，我国超过半数的男性为吸烟者。尽管多数人群研究观察到吸烟增加糖尿病的发生风险，但是也有部分研究显示吸烟与糖尿病发生无关或降低糖尿病的发生风险。机制方面，有研究观察到吸烟可以减轻体质量，从而降低糖尿病的发生风险;而吸烟对升糖激素、胰岛素抵抗的作用尚不明确。该文分别从人群研究和病理生理机制方面探讨了吸烟对糖尿病发生的影响。

关键词: 吸烟, 糖尿病, 流行病学, 机制探讨

Abstract:

The incidence of diabetes is increasing rapidly in recent years. The global incidence of diabetes was 8.3% in 2013 and the number of Chinese patients with diabetes is the largest in the world, about 140 millions. At the same time, there are about 1 billion smokers worldwide and more than half of Chinese males are smokers. Although most population-based studies show that smoking increases the risk of diabetes, some studies indicate that smoking is irrelevant to the incidence of diabetes or decreases the risk of diabetes. The mechanism may be that smoking can reduce the body mass, so as to decrease the risk of diabetes. The effects of smoking on sugar elevating hormones and insulin resistance are not clear yet. This paper discusses the effects of smoking on the incidence of diabetes from the perspectives of population-based studies and pathophysiological mechanisms.

Key words: cigarette smoking, diabetes mellitus, epidemiology, mechanism