上海交通大学学报（医学版）

上海交通大学学报（医学版）

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Omega-3脂肪酸与心血管疾病

程 棣，林 琳，杜 瑞，陆洁莉   

  1. 上海交通大学 医学院附属瑞金医院内分泌代谢病科，上海市内分泌代谢病研究所，上海市内分泌代谢病临床医学中心，上海 200025
  • 出版日期:2016-08-29 发布日期:2016-08-31
  • 通讯作者: 陆洁莉，电子信箱：jielilu@hotmail.com。
  • 作者简介:程 棣（1991—），女，硕士生；电子信箱：690024749@qq.com。
  • 基金资助:

    国家自然科学基金(81370960)；上海市教育委员会高峰高原学科建设计划（20152202）

#br# Omega-3 fatty acids and cardiovascular diseases

#br# CHENG Di, LIN Lin, DU Rui, LU Jie-li   


  1. Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2016-08-29 Published:2016-08-31
  • Supported by:

    National Natural Science Foundation of China, 81370960；Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support，20152202

PDF (PC)

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摘要：

Omega-3系列多不饱和脂肪酸为人体自身不能合成的必需脂肪酸，对人体的作用与二十碳五烯酸（EPA）、二十二碳六烯酸（DHA）的生物活性密切相关。大量研究表明，omega-3脂肪酸具有改善心血管疾病的作用。然而近年来，部分人体研究得出了与此不同的结论。该文回顾了omega-3脂肪酸的主要食物来源、合成路径，并进一步探讨了其对于心血管危险因素的影响、对心血管疾病作用的临床证据及作用机制。

关键词: omega-3, 二十二碳六烯酸, 二十碳五烯酸, 心血管疾病

Abstract:

Omega-3 polyunsaturated fatty acids are essential fatty acids that cannot be synthesized in human body. The effects of omega-3 fatty acids are closely associated with the bioactivity of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Considerable research suggested that omega-3 fatty acids can improve the cardiovascular diseases. However, some studies obtained conflictive results in recent years. This article reviews major dietary sources and synthesis pathways of omega-3 fatty acids and discusses their effects on cardiovascular risk factors, the clinical evidence of cardiovascular protective effect, as well as mechanisms.

Key words: omega-3, docosahexaenoic acid, eicosapentaenoic acid, cardiovascular disease